Jung Barbara, Staudacher Jonas J, Beauchamp Daniel
University of Illinois at Chicago, Chicago, Illinois.
University of Illinois at Chicago, Chicago, Illinois.
Gastroenterology. 2017 Jan;152(1):36-52. doi: 10.1053/j.gastro.2016.10.015. Epub 2016 Oct 20.
Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.
转化生长因子(TGF)-β细胞因子通过复杂的信号通路网络进行信号传导,以调节多种细胞类型中的增殖、分化、黏附、迁移及其他功能。高比例的结直肠癌含有破坏TGF-β家族成员信号传导的突变。我们综述了在结直肠癌发生过程中TGF-β家族成员信号传导是如何改变的、研究模型、信号通路的相互作用以及潜在的治疗策略。