Tiburcio Patricia Denise, Choi Hyunsung, Huang L Eric
Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USA; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USA.
Hypoxia (Auckl). 2014 Jun 18;2:59-70. doi: 10.2147/HP.S50651. eCollection 2014.
Tumor hypoxia has long been recognized as a driving force of malignant progression and therapeutic resistance. The discovery of hypoxia-inducible transcription factors (HIFs) has greatly advanced our understanding of how cancer cells cope with hypoxic stress by maintaining bioenergetics through the stimulation of glycolysis. Until recently, however, it remained perplexing why proliferative cancer cells opt for aerobic glycolysis, an energy-inefficient process of glucose metabolism. Furthermore, the role of HIF in cancer has also become complex. In this review, we highlight recent groundbreaking findings in cancer metabolism, put forward plausible explanations to the complex role of HIF, and underscore remaining issues in cancer biology.
肿瘤缺氧长期以来一直被认为是恶性进展和治疗耐药性的驱动因素。缺氧诱导转录因子（HIFs）的发现极大地推动了我们对癌细胞如何通过刺激糖酵解来维持生物能量学以应对缺氧应激的理解。然而，直到最近，增殖性癌细胞为何选择有氧糖酵解（一种能量效率低下的葡萄糖代谢过程）仍令人困惑。此外，HIF在癌症中的作用也变得复杂起来。在这篇综述中，我们重点介绍了癌症代谢领域最近的突破性发现，对HIF的复杂作用提出了合理的解释，并强调了癌症生物学中尚存的问题。
