Chou T-C, Tsai K-B, Wu C-Y, Hong C-H, Lee C-H
Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.
Department of Pathology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan.
Clin Exp Dermatol. 2016 Dec;41(8):902-905. doi: 10.1111/ced.12954. Epub 2016 Oct 23.
We present a case of Merkel cell carcinoma (MCC) coincident with squamous cell carcinoma (SCC) on the breast of a woman with chronic arsenism. This case demonstrates the distinct association of chronic arsenism with two different primary cutaneous carcinomas. Merkel cell polyomavirus (MCPyV) was identified in the lesional skin of the MCC but not in that of the SCC, suggesting there are different interactions of MCPyV in the pathogenesis of SCC and MCC related to arsenic. Physicians need to be vigilant in the occurrence of both SCC and MCC in patients with chronic arsenism. To our knowledge, this is the first study to show the presence of MCPyV in the MCC but not the SCC portion of an arsenic-induced tumour.
我们报告了一例慢性砷中毒女性患者乳房上同时出现默克尔细胞癌（MCC）和鳞状细胞癌（SCC）的病例。该病例表明慢性砷中毒与两种不同的原发性皮肤癌存在明显关联。在MCC的皮损中检测到默克尔细胞多瘤病毒（MCPyV），而在SCC的皮损中未检测到，这表明MCPyV在与砷相关的SCC和MCC发病机制中存在不同的相互作用。医生需要警惕慢性砷中毒患者中SCC和MCC的发生。据我们所知，这是第一项显示MCPyV存在于砷诱导肿瘤的MCC部分而非SCC部分的研究。
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