Iwasaki Y, Kinoshita M, Ikeda K
Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Japan.
Int J Neurosci. 1989 Jun;46(3-4):97-100. doi: 10.3109/00207458908986245.
Studies with organotypic culture of ventral spinal cord revealed that leupeptin, a protease inhibitor at 10(-4) to 10(-10) M exerts a marked growth-stimulating effect. The presence of leupeptin, the neuritic extension of ventral spinal cord exceeds control values 1.5-4.9 times. The growth zone of spinal cord explants increases in the leupeptin treated cultures. The possible mechanism of trophic effect of leupeptin on cultured ventral spinal cord was briefly discussed.
