Petersen J M, Caride V J, Prokop E K, Troncale F J, McCallum R W
Department of Medicine, Yale University School of Medicine, Hospital of Saint Raphael, New Haven, CT 06511.
Int J Rad Appl Instrum B. 1989;16(4):389-95. doi: 10.1016/0883-2897(89)90106-2.
Gastric emptying studies were performed on nine healthy volunteers and ten duodenal ulcer (DU) patients utilizing a dual radionuclide technique to assess simultaneously emptying rates of liquid (111In labeled water) and solid (99mTc sulfur colloid labeled chicken liver) components of a meal. One gram of sucralfate was compared to placebo in separate days in a randomized double-blind crossover fashion. Subjects ingested the radiolabeled test meal 1 h after receiving medication, and gastric emptying was monitored for 3 h using a gamma camera interfaced with a computer. We found that DU patients had significantly faster gastric emptying of solids (P less than 0.05) compared to normals on the placebo days, while liquid emptying rates were similar. Sucralfate, in the DU patients, significantly (P less than 0.05) slowed gastric emptying of water from 20 to 40 min and emptying of the solid component from 100-160 min after the meal compared to placebo. In normal subjects, gastric emptying of liquids and solids was not significantly affected by sucralfate. We conclude that slowing of gastric emptying, possibly mediated through aluminum ions, occurs in DU patients on sucralfate. This may be one mechanism by which sucralfate enhances healing and decreases recurrence of duodenal ulcer.
利用双放射性核素技术对9名健康志愿者和10名十二指肠溃疡（DU）患者进行了胃排空研究，以同时评估一餐中液体（111铟标记水）和固体（99m锝硫胶体标记鸡肝）成分的排空率。在不同日期，以随机双盲交叉方式将1克硫糖铝与安慰剂进行比较。受试者在服药1小时后摄入放射性标记测试餐，并使用与计算机相连的γ相机监测胃排空3小时。我们发现，在服用安慰剂的日子里，与正常人相比，DU患者固体的胃排空明显更快（P<0.05），而液体排空率相似。与安慰剂相比，DU患者服用硫糖铝后，在进食后20至40分钟内水的胃排空以及100至160分钟内固体成分的胃排空显著减慢（P<0.05）。在正常受试者中，硫糖铝对液体和固体的胃排空没有显著影响。我们得出结论，服用硫糖铝的DU患者胃排空减慢，可能是由铝离子介导的。这可能是硫糖铝促进愈合和降低十二指肠溃疡复发率的一种机制。
