Van Epps P, Oswald D, Higgins P A, Hornick T R, Aung H, Banks R E, Wilson B M, Burant C, Graventstein S, Canaday D H
Geriatric Research, Education, and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, OH USA ; Division of Infectious Disease, Case Western Reserve University, Cleveland, OH USA.
Division of Infectious Disease, Case Western Reserve University, Cleveland, OH USA.
Immun Ageing. 2016 Oct 19;13:27. doi: 10.1186/s12979-016-0082-z. eCollection 2016.
Upregulation of pro-inflammatory cytokines has not only been associated with increased morbidity and mortality in older adults but also has been linked to frailty. In the current study we aimed to compare the relative relationship of age and frailty on inflammation and thrombosis in older veterans.
We analyzed 117 subjects (age range 62-95 years; median 81) divided into 3 cohorts: non-frail, pre-frail and frail based on the Fried phenotype of frailty. Serum inflammatory markers were determined using commercially available ELISA kits. Frail and pre-frail (PF) subjects had higher levels than non-frail (NF) subjects of IL-6 (NF vs. PF: = 0.002; NF vs. F: < 0.001), TNFR1 (NF vs. F: = 0.012), TNFRII (NF vs. F: 0.002; NF vs. PF: = 0.005) and inflammatory index: = 0.333log(IL-6) + 0.666log(sTNFR1) (NF vs. F: = 0.009; NF vs. PF: < 0.001). Frailty status explained a greater percent of variability in markers of inflammation than age: IL-6 (12 % vs. 0.3 %), TNFR1 (5 % vs. 4 %), TNFR2 (11 % vs. 6 %), inflammatory index (16 % vs. 8 %). Aging was significantly associated with higher fibrinogen ( = 0.04) and D-dimer levels ( = 0.01) but only among NF subjects.
In conclusion, these data suggest that among older veterans, frailty status has a stronger association with inflammation and the inflammatory index than age does. Larger studies, in more diverse populations are needed to confirm these findings.
促炎细胞因子的上调不仅与老年人发病率和死亡率增加有关，还与虚弱相关。在本研究中，我们旨在比较年龄和虚弱对老年退伍军人炎症和血栓形成的相对关系。
我们分析了117名受试者（年龄范围62 - 95岁；中位数81岁），根据Fried虚弱表型分为3组：非虚弱组、虚弱前期组和虚弱组。使用市售ELISA试剂盒测定血清炎症标志物。虚弱组和虚弱前期组（PF）受试者的IL - 6水平高于非虚弱组（NF）受试者（NF vs. PF：= 0.002；NF vs. F：< 0.001），TNFR1（NF vs. F：= 0.012），TNFRII（NF vs. F：0.002；NF vs. PF：= 0.005）以及炎症指数：= 0.333 * log(IL - 6) + 0.666 * log(sTNFR1)（NF vs. F：= 0.009；NF vs. PF：< 0.001）。与年龄相比，虚弱状态在炎症标志物变异性中所占比例更大：IL - 6（12%对0.3%），TNFR1（5%对4%），TNFR2（11%对6%），炎症指数（16%对8%）。衰老仅在NF受试者中与较高的纤维蛋白原水平（= 0.04）和D - 二聚体水平（= 0.01）显著相关。
总之，这些数据表明，在老年退伍军人中，虚弱状态与炎症及炎症指数的关联比年龄更强。需要在更多样化人群中进行更大规模的研究来证实这些发现。
