减重手术对脂肪性肝病谱的影响。
The Effect of Bariatric Surgery on the Spectrum of Fatty Liver Disease.
机构信息
Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Department of Surgery, University of Calgary, Calgary, AB, Canada.
出版信息
Can J Gastroenterol Hepatol. 2016;2016:2059245. doi: 10.1155/2016/2059245. Epub 2016 Sep 29.
Abstract
Nonalcoholic fatty liver disease is becoming one of the most common causes of liver disease in the western world. The most significant risk factors are obesity and the metabolic syndrome for which bariatric surgery has been shown to be an effective treatment. However, the effects of bariatric surgery on nonalcoholic fatty liver disease, specifically liver fibrosis and cirrhosis, are not well established. We review published bariatric surgery outcomes with respect to nonalcoholic liver disease. On the basis of this review we suggest that bariatric surgery may provide a viable treatment option for the treatment of nonalcoholic fatty liver disease, including patients with fibrosis and compensated cirrhosis, and that this topic should be a target of future investigation.
摘要
非酒精性脂肪性肝病正成为西方世界最常见的肝病病因之一。肥胖和代谢综合征是非酒精性脂肪性肝病最重要的危险因素，减重手术已被证明是一种有效的治疗方法。然而，减重手术对非酒精性脂肪性肝病（特别是肝纤维化和肝硬化）的影响尚未得到充分证实。我们就减重手术治疗非酒精性肝病的相关研究进行综述。基于这篇综述，我们提出减重手术可能为非酒精性脂肪性肝病的治疗提供一种可行的治疗选择，包括纤维化和代偿性肝硬化患者，该主题应成为未来研究的目标。
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