de Souza Leão Kamamoto Cristhine, Sanudo Adriana, Hassun Karime M, Bagatin Ediléia
Department of Dermatology, Universidade Federal de São Paulo (Federal University of São Paulo [UNIFESP]), São Paulo, SP, Brazil.
Department of Preventive Medicine, Universidade Federal de São Paulo (Federal University of São Paulo [UNIFESP]), São Paulo, SP, Brazil.
Int J Dermatol. 2017 Jan;56(1):80-85. doi: 10.1111/ijd.13408. Epub 2016 Oct 25.
The efficacy of low-dose oral isotretinoin in the treatment of seborrhea and seborrheic dermatitis has been poorly investigated in randomized studies.
This study was designed to determine the efficacy and safety of low-dose oral isotretinoin in the treatment of moderate to severe seborrhea and seborrheic dermatitis on the scalp and/or face.
A randomized, comparative clinical trial, using two groups, was conducted over 6 months. Patients in Group ISO were treated with isotretinoin 10 mg every other day. In Group X, patients received antiseborrheic topical treatment. Patient opinion, investigator assessment, scalp pruritus, sebum production, and quality of life (QoL) comprised the efficacy outcomes.
The intention-to-treat population comprised a total of 45 patients with mean ± standard deviation ages of 28.7 ± 5.8 years in Group ISO and 29.8 ± 6.5 years in Group X. The rate of sebum production significantly decreased in Group ISO. Patient opinion, investigator, and QoL assessments improved in both groups.
Low-dose oral isotretinoin can be a therapeutic modality for moderate to severe seborrhea and seborrheic dermatitis.
在随机研究中，低剂量口服异维A酸治疗脂溢性皮炎的疗效研究较少。
本研究旨在确定低剂量口服异维A酸治疗头皮和/或面部中重度脂溢性皮炎的疗效和安全性。
进行了一项为期6个月的随机对照临床试验，分为两组。ISO组患者每隔一天服用10毫克异维A酸。X组患者接受抗脂溢性局部治疗。疗效指标包括患者意见、研究者评估、头皮瘙痒、皮脂分泌和生活质量（QoL）。
意向性治疗人群共有45例患者，ISO组平均年龄±标准差为28.7±5.8岁，X组为29.8±6.5岁。ISO组皮脂分泌率显著降低。两组患者的意见、研究者评估和生活质量评估均有所改善。
低剂量口服异维A酸可作为中重度脂溢性皮炎的一种治疗方式。
