Geng Bin, Wang Jing, Ma Jing-Lin, Zhang Bo, Jiang Jin, Tan Xiao-Yi, Xia Ya-Yi
Department of Orthopaedics, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730000; Orthopaedics Key Laboratory of Gansu Province, Lanzhou, Gansu 730000, China.
Orthopaedics Key Laboratory of Gansu Province, Lanzhou, Gansu 730000, China.
Chin Med J (Engl). 2016 Nov 5;129(21):2540-2545. doi: 10.4103/0366-6999.192771.
Few data are available concerning intercondylar notch dimensions in female nonathletes with knee osteoarthritis (OA) in plateau region. The aim of this study was to assess the relation of intercondylar notch morphology to anterior cruciate ligament (ACL) injuries in female nonathletes with knee OA aged 41-65 years from the Chinese Loess Plateau.
The study was conducted on 330 patients with ACL injury (aged 31-65 years; 159 males, 171 females), 141 patients with OA (aged 31-65 years; 59 males, 82 females), and 89 female healthy controls (aged 41-65 years), and this evaluation included identifying the distribution of patients with OA or ACL injury and measuring the intercondylar notch width indexes (NWIs).
There was a significant rising trend in patients with OA (the Kellgren and Lawrence grade = 3) with ACL injury (OA-S + ACL) aged 41-65 years, especially in females. We found that the notches of OA-S + ACL had a smaller NWI compared with control and OA without ACL injury (OA-S-only, P = 0.000, 95% confidence interval [CI] = -0.059--0.030; P = 0.000, 95% CI = -0.049--0.016). A similar trend was found in notch shape index (NSI), but not in notch depth index and the cross-sectional area. The cutoff of NWI and NSI value was 0.26, and 0.65, and area under the receiver operating characteristic curve was 0.82, and 0.79, respectively. Further study displayed a significant correlation between a reduced NWI and NSI and OA-S + ACL (P = 0.000, χ2 = 14.012; P = 0.000, χ2 = 14.286).
A narrower intercondylar notch and a plateau environment are risk factors of predisposing female nonathletes with knee OA to ACL injury aged 41-65 years.
关于高原地区患有膝关节骨关节炎（OA）的非运动员女性髁间切迹尺寸的数据较少。本研究的目的是评估中国黄土高原地区41至65岁患有膝关节OA的非运动员女性的髁间切迹形态与前交叉韧带（ACL）损伤之间的关系。
本研究对330例ACL损伤患者（年龄31至65岁；男性159例，女性171例）、141例OA患者（年龄31至65岁；男性59例，女性82例）和89例健康女性对照者（年龄41至65岁）进行，该评估包括确定OA或ACL损伤患者的分布情况并测量髁间切迹宽度指数（NWIs）。
41至65岁患有ACL损伤的OA患者（Kellgren和Lawrence分级=3级）（OA-S + ACL）有显著上升趋势，尤其是在女性中。我们发现，与对照组和无ACL损伤的OA患者（仅OA-S）相比，OA-S + ACL患者的切迹NWIs更小（P = 0.000，95%置信区间[CI]= -0.059--0.030；P = 0.000，95% CI = -0.049--0.016）。在切迹形状指数（NSI）中发现了类似趋势，但在切迹深度指数和横截面积中未发现。NWI和NSI值的截断值分别为0.26和0.65，受试者工作特征曲线下面积分别为0.82和0.79。进一步研究显示，NWI和NSI降低与OA-S + ACL之间存在显著相关性（P = 0.000，χ2 = 14.012；P = 0.000，χ2 = 14.286）。
较窄的髁间切迹和高原环境是使41至65岁患有膝关节OA的非运动员女性易发生ACL损伤的危险因素。
