Fattouh Kinda, Collet-Benzaquen Diane, Provensal Anne M, Desseigne Françoise, Castillo Christine, Combemale Patrick, de la Fouchardière Arnaud
*Service de dermatologie, Hôpital Edouard Herriot, Lyon, France; †Service de pathologie, Hôpital Edouard Herriot, Lyon, France; ‡Département d'oncologie médicale, Centre Léon Bérard, Lyon, France; and §Département de Biopathologie, Centre Léon Bérard, Lyon, France.
Am J Dermatopathol. 2017 Oct;39(10):764-766. doi: 10.1097/DAD.0000000000000743.
Necrotizing Infundibular Crystalline Folliculitis (NICF) is rare entity of unknown pathogenesis presenting as follicular crystalline papules arising in seborrheic areas. We report 2 cases of NICF in patients under targeted therapy for metastatic adenocarcinoma. In one case, the lesions reappeared cyclically every 3 weeks after each injection and in the other case, lesions persisted until disruption of the continuous oral therapy. Punch-biopsies demonstrated folliculitis with a plugging crystalline material associated with either bacteria or yeast. These are the first descriptions of drug-induced NICF.
坏死性漏斗状结晶性毛囊炎（NICF）是一种发病机制不明的罕见疾病，表现为脂溢性区域出现的毛囊结晶性丘疹。我们报告了2例接受转移性腺癌靶向治疗的患者发生NICF的病例。1例患者，每次注射后病变每3周周期性复发；另1例患者，病变持续存在直至中断持续口服治疗。打孔活检显示毛囊炎伴与细菌或酵母相关的结晶性物质堵塞。这些是药物性NICF的首次描述。
