Beaufrère Aurélie, Garcia Valérie, Frochot Vincent, Molina Thierry, Daudon Michel, Fraitag Sylvie
Department of Pathology, Necker-Enfants Malades Hospital, APHP, Paris, France.
Cabinet de Dermatologie, Guyancourt, France.
Am J Dermatopathol. 2018 Jan;40(1):e9-e11. doi: 10.1097/DAD.0000000000000964.
Necrotizing infundibular crystalline folliculitis (NICF) is a rare disorder, which was described for the first time by Lucke et al in 1999. NICF is characterized by multiple folliculocentric papules with a predilection for occurring in seborrheic areas in adults and corresponding dilated follicular ostia containing crystalline material. The precise pathogenesis and nature of this crystalline material are currently unknown. Here, we report an unusual case of NICF presented as an uncommon generalized skin rash in an adolescent. In addition, we present analysis using infrared microscopy for improved characterization of this crystalline material. Similar to previous cases, a biopsy revealed a dilated follicular ostium with the appearance of containing crystalline material associated with parakeratosis. Infrared microscopy analysis produced specific spectral features of calcium palmitate.
坏死性漏斗状结晶性毛囊炎（NICF）是一种罕见的疾病，由卢克等人于1999年首次描述。NICF的特征是多个以毛囊为中心的丘疹，好发于成人的脂溢性区域，相应的毛囊开口扩张并含有结晶物质。这种结晶物质的确切发病机制和性质目前尚不清楚。在此，我们报告一例不寻常的NICF病例，该病例表现为一名青少年身上罕见的全身性皮疹。此外，我们还展示了使用红外显微镜对这种结晶物质进行更好表征的分析。与之前的病例相似，活检显示毛囊开口扩张，外观上含有与角化不全相关的结晶物质。红外显微镜分析产生了棕榈酸钙的特定光谱特征。
