Popova N A, Kaledin V I, Nikolin V P, Bogdanova L A, Morozkova T S, Tornuev Yu V
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Novosibirsk National Research University, Novosibirsk, Russia.
Bull Exp Biol Med. 2016 Oct;161(6):811-815. doi: 10.1007/s10517-016-3518-8. Epub 2016 Oct 26.
Experiments were performed on the model of transplanted mouse tumor with high incidence of liver metastases. Hydrophilic drug cycloplatam (injected intravenously in liposomes) was more potent than "free cycloplatam" (injected intravenously or intraperitoneally in physiological saline) in inhibiting the growth of natural and experimental metastases in the liver. By contrast, liposomal cycloplatam had lower efficiency than free cycloplatam in suppressing the growth of solid tumor. Liposomal and free cortifen (hydrophobic hormonal cytostatic) produced nearly the same effects on solid tumor growth. Our results suggest that liposomal forms of hydrophobic compounds producing nonselective effect on tumor cells (e.g., actinomycin D or Cosmegen), should not have advantages over free forms.
在具有高肝转移发生率的小鼠移植瘤模型上进行了实验。亲水性药物环铂（脂质体静脉注射）在抑制肝脏自然转移和实验性转移的生长方面比“游离环铂”（生理盐水静脉或腹腔注射）更有效。相比之下，脂质体环铂在抑制实体瘤生长方面的效率低于游离环铂。脂质体和游离皮质酮（疏水性激素细胞抑制剂）对实体瘤生长产生的影响几乎相同。我们的结果表明，对肿瘤细胞产生非选择性作用的疏水性化合物的脂质体形式（例如放线菌素D或更生霉素）不应比游离形式具有优势。
