Bukrinskaya A G, Petrova I G, Prokazova N V, Zvezdina N D, Bergelson L D
Central Institute for Postgraduate Training of Physicians, Moscow, U.S.S.R.
J Gen Virol. 1989 Sep;70 ( Pt 9):2433-7. doi: 10.1099/0022-1317-70-9-2433.
Influenza virus infection in mice may be either stimulated or partially prevented by certain gangliosides, depending on the experimental conditions employed. When injected prior to virus infection gangliosides increased the mortality rate, whereas preincubation with the virus before infection had a protecting effect. Hybrid mice resistant to influenza virus became highly susceptible to infection after injection of a specific ganglioside whereas the corresponding antiganglioside antiserum protected virus-susceptible mice against infection by the virus. These results are discussed in the light of earlier findings that various gangliosides enhance non-specific binding of influenza virus, whereas gangliosides of the GT1b and GD1b type are able to act as specific virus receptors and to promote virus penetration.
根据所采用的实验条件，某些神经节苷脂可能会刺激或部分预防小鼠感染流感病毒。在病毒感染前注射神经节苷脂会增加死亡率，而在感染前与病毒预孵育则具有保护作用。对流感病毒有抗性的杂种小鼠在注射特定神经节苷脂后变得极易感染，而相应的抗神经节苷脂抗血清则可保护易感染病毒的小鼠免受该病毒感染。根据早期的研究结果对这些结果进行了讨论，早期研究发现各种神经节苷脂可增强流感病毒的非特异性结合，而GT1b和GD1b型神经节苷脂能够作为特异性病毒受体并促进病毒穿透。
