Ishizaki F, Harada T, Kito S, Harada A, Saeki M, Nakamura S
Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Hiroshima J Med Sci. 1991 Jun;40(2):83-5.
We reported the case of a 74-year-old woman suffering from essential tremor for 20 years which was treated effectively with purified bovine brain gangliosides containing GM1, GD1a, GD1b and GT1b gangliosides. The trials of the treatment were conducted twice, 40 mg and 20 mg gangliosides per day respectively administered intramuscularly. Essential tremor dramatically improved with gangliosides on the second day of treatment, suggesting that the effect of gangliosides was not induced by neuronal sprouting or regeneration. It is speculated that a certain type of essential tremor is a reversible disease of membrane disorder.
我们报告了一例患有特发性震颤20年的74岁女性病例，其通过含有GM1、GD1a、GD1b和GT1b神经节苷脂的纯化牛脑苷脂得到有效治疗。治疗试验进行了两次，分别每天肌肉注射40毫克和20毫克神经节苷脂。在治疗的第二天，特发性震颤因神经节苷脂而显著改善，这表明神经节苷脂的作用不是由神经元发芽或再生诱导的。据推测，某种类型的特发性震颤是一种膜紊乱的可逆性疾病。
