[血液系统恶性肿瘤中坏死性凋亡的研究进展——综述]

[Research Progress of Necroptosis in Hematological Malignancies -Review].

作者信息

Chi Zuo-Fei, Yang Wei, He Qiu-Ying, Fu Shuang, Fu Yu

机构信息

Department of Pediatric Hematology,Shengjing Hospital of China Medical University,Shenyang 110022, Liaoning Province, China.

Second Department of Hematology,Shengjing Hospital of China Medical University,Shenyang 110022, Liaoning Province, China. E-mail:

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Oct;24(5):1588-1593. doi: 10.7534/j.issn.1009-2137.2016.05.055.

DOI:10.7534/j.issn.1009-2137.2016.05.055

PMID:27784398

Abstract

Necroptosis is a novel programmed cell death mechanism which is characterized by a necrotic morphology, but the necroptosis is precisely regulated by cellular signaling pathway just like apoptosis. Recently, many reports have revealed that necroptosis contributes to the pathogenesis of inflammation, ischemic reperfusion injury and tumour. Hematological malignancies are a set of hemotopathy diseases with poor prognosis. In this review, the research progress of signaling pathway of necroptosis and its role in hematological malignancies are summarized.

摘要

坏死性凋亡是一种以坏死形态为特征的新型程序性细胞死亡机制，但与凋亡一样，坏死性凋亡也受细胞信号通路的精确调控。最近，许多报道表明，坏死性凋亡与炎症、缺血再灌注损伤和肿瘤的发病机制有关。血液系统恶性肿瘤是一组预后较差的血液病。在这篇综述中，总结了坏死性凋亡信号通路的研究进展及其在血液系统恶性肿瘤中的作用。