Marson Lesley, Giamberardino Maria Adele, Costantini Raffaele, Czakanski Peter, Wesselmann Ursula
University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
"G. D'Annunzio" University-Pathophysiology of Pain Laboratory, Chieti, Italy.
Sex Med Rev. 2013 Jul;1(2):108-122. doi: 10.1002/smrj.14. Epub 2015 Oct 18.
Significant progress has been made in elucidating the physiological and pharmacological mechanisms of female sexual function through preclinical animal research. The continued development of animal models is vital for the understanding and treatment of the many diverse disorders that occur in women.
To provide an updated review of the experimental models evaluating female sexual function that may be useful for clinical translation.
Review of English written, peer-reviewed literature, primarily from 2000 to 2012, that described studies on female sexual behavior related to motivation, arousal, physiological monitoring of genital function and urogenital pain.
Analysis of supporting evidence for the suitability of the animal model to provide measurable indices related to desire, arousal, reward, orgasm, and pelvic pain.
The development of female animal models has provided important insights in the peripheral and central processes regulating sexual function. Behavioral models of sexual desire, motivation, and reward are well developed. Central arousal and orgasmic responses are less well understood, compared with the physiological changes associated with genital arousal. Models of nociception are useful for replicating symptoms and identifying the neurobiological pathways involved. While in some cases translation to women correlates with the findings in animals, the requirement of circulating hormones for sexual receptivity in rodents and the multifactorial nature of women's sexual function requires better designed studies and careful analysis. The current models have studied sexual dysfunction or pelvic pain in isolation; combining these aspects would help to elucidate interactions of the pathophysiology of pain and sexual dysfunction.
Basic research in animals has been vital for understanding the anatomy, neurobiology, and physiological mechanisms underlying sexual function and urogenital pain. These models are important for understanding the etiology of female sexual function and for future development of pharmacological treatments for sexual dysfunctions with or without pain. Marson L, Giamberardino MA, Costantini R, Czakanski P, and Wesselmann U. Animal models for the study of female sexual dysfunction. Sex Med Rev 2013;1:108-122.
通过临床前动物研究，在阐明女性性功能的生理和药理机制方面已取得重大进展。动物模型的持续发展对于理解和治疗女性发生的多种不同疾病至关重要。
对评估女性性功能的实验模型进行更新综述，这些模型可能有助于临床转化。
回顾主要从2000年至2012年以英文撰写并经同行评审的文献，这些文献描述了与动机、唤起、生殖器功能的生理监测及泌尿生殖系统疼痛相关的女性性行为研究。
分析动物模型适用性的支持证据，以提供与性欲、唤起、奖赏、性高潮和盆腔疼痛相关的可测量指标。
雌性动物模型的发展为调节性功能的外周和中枢过程提供了重要见解。性欲、动机和奖赏的行为模型已得到充分发展。与生殖器唤起相关的生理变化相比，中枢唤起和性高潮反应的了解较少。伤害感受模型有助于复制症状并识别所涉及的神经生物学途径。虽然在某些情况下向女性的转化与动物研究结果相关，但啮齿动物性接受所需的循环激素以及女性性功能的多因素性质需要设计更好的研究并进行仔细分析。目前的模型孤立地研究性功能障碍或盆腔疼痛；将这些方面结合起来将有助于阐明疼痛和性功能障碍病理生理学的相互作用。
动物基础研究对于理解性功能和泌尿生殖系统疼痛的解剖学、神经生物学和生理机制至关重要。这些模型对于理解女性性功能的病因以及未来开发有或无疼痛的性功能障碍的药物治疗很重要。马森L、詹贝拉迪诺MA、科斯坦蒂尼R、察坎斯基P和韦塞尔曼U。用于研究女性性功能障碍的动物模型。性医学评论2013；1：108 - 122。
