Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Madigan Healthcare System, Tacoma, Washington, USA.
Fertil Steril. 2012 Sep;98(3):511-9. doi: 10.1016/j.fertnstert.2012.06.029. Epub 2012 Jul 20.
Originally described over three hundred years ago, endometriosis is classically defined by the presence of endometrial glands and stroma in extrauterine locations. Endometriosis is an inflammatory, estrogen-dependent condition associated with pelvic pain and infertility. This work reviews the disease process from theories regarding origin to the molecular basis for disease sequelae. A thorough understanding of the histopathogenesis and pathophysiology of endometriosis is essential to the development of novel diagnostic and treatment approaches for this debilitating condition.
虽然早在三百多年前就有相关记载,但直到现在,子宫内膜异位症仍被经典地定义为在子宫以外的部位存在子宫内膜腺体和间质。它是一种炎症性、雌激素依赖性疾病,与盆腔疼痛和不孕有关。本文从发病机制理论到疾病后果的分子基础对该病进行综述。深入了解子宫内膜异位症的组织发生和病理生理学对于开发这种使人衰弱的疾病的新的诊断和治疗方法至关重要。