妊娠滋养细胞肿瘤治疗期间严重甲氨蝶呤超敏反应：病例报告及管理考量
Severe methotrexate hypersensitivity during treatment for Gestational trophoblastic Neoplasia: Case Report and considerations for management.
作者信息
Kar Ayesha, Mills Kathryn A
机构信息
University of Chicago, Department of Obstetrics & Gynecology, Section of Gynecologic Oncology.
出版信息
Gynecol Oncol Rep. 2024 Mar 9;52:101364. doi: 10.1016/j.gore.2024.101364. eCollection 2024 Apr.
Abstract
•Methotrexate (MTX) hypersensitivity is rare and has not been widely reported in the setting of treatment of GTN.•Work up of hypersensitivity reactions may include consultation to an allergist, serum tryptase level, and possible skin testing.•In low-risk GTN, dactinomycin should be utilized after a hypersensitivity reaction to MTX.
摘要
•甲氨蝶呤（MTX）超敏反应罕见，在妊娠滋养细胞肿瘤（GTN）治疗中尚未有广泛报道。
•超敏反应的检查可能包括咨询过敏专科医生、检测血清类胰蛋白酶水平以及可能进行皮肤试验。
•在低风险GTN中，对MTX发生超敏反应后应使用放线菌素D。
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