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2
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pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature.低危葡萄胎后妊娠滋养细胞肿瘤患者甲氨蝶呤治疗并发肺炎：一例报告及文献复习
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Predictive factors associated with resistance to initial methotrexate treatment in women with low-risk gestational trophoblastic neoplasia.与低危型妊娠滋养细胞肿瘤女性患者对初始甲氨蝶呤治疗耐药相关的预测因素。
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本文引用的文献

1
Direct comparisons of efficacy and safety between actinomycin-D and methotrexate in women with low-risk gestational trophoblastic neoplasia: a meta-analysis of randomized and high-quality non-randomized studies.比较低危型妊娠滋养细胞肿瘤患者应用放线菌素 D 和甲氨蝶呤的疗效和安全性：一项随机和高质量非随机研究的荟萃分析。
BMC Cancer. 2021 Oct 18;21(1):1122. doi: 10.1186/s12885-021-08849-7.
2
Incidence of Hypersensitivity Reactions to Carboplatin or Paclitaxel in Patients With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer With or Without or Mutations.患有或不患有 或 突变的卵巢癌、输卵管癌或原发性腹膜癌患者对卡铂或紫杉醇过敏反应的发生率。
J Adv Pract Oncol. 2019 Jul;10(5):428-439. doi: 10.6004/jadpro.2019.10.5.2. Epub 2019 Jul 1.
3
Adverse Effects of Low-Dose Methotrexate: A Randomized Trial.低剂量甲氨蝶呤的不良反应：一项随机试验。
Ann Intern Med. 2020 Mar 17;172(6):369-380. doi: 10.7326/M19-3369. Epub 2020 Feb 18.
4
Gestational Trophoblastic Neoplasia, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.妊娠滋养细胞肿瘤，2.2019 年版，NCCN 肿瘤学临床实践指南。
J Natl Compr Canc Netw. 2019 Nov 1;17(11):1374-1391. doi: 10.6004/jnccn.2019.0053.
5
Methotrexate hypersensitivity reactions in pediatrics: Evaluation and management.儿科甲氨蝶呤超敏反应：评估与管理
Pediatr Blood Cancer. 2017 May;64(5). doi: 10.1002/pbc.26306. Epub 2016 Oct 27.
6
15years of progress in gestational trophoblastic disease: Scoring, standardization, and salvage.15 年来妊娠滋养细胞疾病的进展：评分、标准化和挽救治疗。
Gynecol Oncol. 2017 Jan;144(1):200-207. doi: 10.1016/j.ygyno.2016.08.330. Epub 2016 Oct 13.
7
Successful desensitization to low-dose methotrexate.
Rheumatology (Oxford). 2013 Dec;52(12):2305-6. doi: 10.1093/rheumatology/ket183. Epub 2013 May 16.
8
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.妊娠滋养细胞疾病 I：流行病学、病理学、临床表现和诊断、葡萄胎的处理。
Am J Obstet Gynecol. 2010 Dec;203(6):531-9. doi: 10.1016/j.ajog.2010.06.073. Epub 2010 Aug 21.
9
Gestational trophoblastic disease.妊娠滋养细胞疾病。
Lancet. 2010 Aug 28;376(9742):717-29. doi: 10.1016/S0140-6736(10)60280-2. Epub 2010 Jul 29.
10
Serum tryptase levels and markers of renal dysfunction in a population with chronic kidney disease.慢性肾脏病患者的血清胰蛋白酶水平与肾功能障碍标志物。
J Nephrol. 2010 May-Jun;23(3):282-90.

妊娠滋养细胞肿瘤治疗期间严重甲氨蝶呤超敏反应：病例报告及管理考量

Severe methotrexate hypersensitivity during treatment for Gestational trophoblastic Neoplasia: Case Report and considerations for management.

作者信息

Kar Ayesha, Mills Kathryn A

机构信息

University of Chicago, Department of Obstetrics & Gynecology, Section of Gynecologic Oncology.

出版信息

Gynecol Oncol Rep. 2024 Mar 9;52:101364. doi: 10.1016/j.gore.2024.101364. eCollection 2024 Apr.

DOI:10.1016/j.gore.2024.101364
PMID:38495802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10940130/
Abstract

•Methotrexate (MTX) hypersensitivity is rare and has not been widely reported in the setting of treatment of GTN.•Work up of hypersensitivity reactions may include consultation to an allergist, serum tryptase level, and possible skin testing.•In low-risk GTN, dactinomycin should be utilized after a hypersensitivity reaction to MTX.

摘要

•甲氨蝶呤（MTX）超敏反应罕见，在妊娠滋养细胞肿瘤（GTN）治疗中尚未有广泛报道。

•超敏反应的检查可能包括咨询过敏专科医生、检测血清类胰蛋白酶水平以及可能进行皮肤试验。

•在低风险GTN中，对MTX发生超敏反应后应使用放线菌素D。