[Production of experimental infective endocarditis in rabbit mitral valve prolapse induced by vagus stimulation].

An experimental model of bacterial endocarditis was developed in rabbits with mitral valve prolapse which was induced by vagus stimulation. Endocarditis was produced by injecting bacteria including pseudomonas pseudoalkaligenes (pathogenic for rabbits) and streptococcus viridans taken from human beings. Both bacteria induced bacterial endocarditis with high incidence, which was augmented by higher dose or earlier administration of bacterial after producing mitral valve prolapse. Similarly, verruca was produced more frequently by higher dose of bacteria or earlier administration of bacteria. The present data are similar to those of human beings, so that it is helpful to a study of bacterial endocarditis in a clinical setting.