Imataka K, Kitahara Y
The Institute for Adult Diseases, Asahi Life Foundation, Tokyo.
J Cardiol Suppl. 1987;14:21-36.
Mitral valve and papillary muscle lesions were experimentally produced in rabbits by cervical vagal stimulation or compression of the abdominal aorta. The involvement induced the similar findings to mitral valve prolapse in human beings including mid-systolic clicks and a late systolic or holosystolic murmur. Extrasystoles were also common. Necropsies disclosed papillary muscle swelling, bleeding and edematous change in the mitral valve, swelling of the myocardial cells and interstitial fibrosis. Further, bacterial endocarditis was induced in such rabbits by injecting pseudomonas alkaligenes. Possible connection of experimentally-induced lesions of the mitral complex and mitral valve prolapse in human beings was discussed.
通过颈迷走神经刺激或腹主动脉压迫在兔身上实验性地制造二尖瓣和乳头肌病变。这种病变引发了与人类二尖瓣脱垂相似的表现，包括收缩中期喀喇音和收缩晚期或全收缩期杂音。期前收缩也很常见。尸检发现乳头肌肿胀、二尖瓣出血和水肿变化、心肌细胞肿胀以及间质纤维化。此外，通过注射产碱假单胞菌在这些兔身上诱发了细菌性心内膜炎。文中讨论了实验诱导的二尖瓣复合体病变与人类二尖瓣脱垂之间可能的联系。
