Lee Tau Hong, Lee Linda Kay, Lye David Chien, Leo Yee Sin
a Communicable Disease Centre, Institute of Infectious Diseases and Epidemiology , Tan Tock Seng Hospital , Singapore , Singapore.
b Yong Loo Lin School of Medicine , National University of Singapore , Singapore , Singapore.
Expert Rev Anti Infect Ther. 2017 Jan;15(1):67-78. doi: 10.1080/14787210.2017.1248405. Epub 2016 Oct 27.
Traditionally a disease mainly affecting the pediatric population, dengue burden has increased significantly in recent decades and adults with severe disease may become more common. There is currently no effective anti-viral agent available for the treatment of dengue and supportive care is the mainstay of management. Areas covered: We present a review of current literature on dengue severity classification systems and the management of severe dengue in adults. In particular, emphasis was placed on organ impairment in dengue and management of elderly individuals with multiple medical problems. Expert commentary: There is an urgent need to search for an effective anti-viral agent to treat infected individuals. The commercial availability of a dengue vaccine in older children has provided optimism in reducing the disease burden but long term efficacy and safety are unknown. The results from phase III trials of two new candidate vaccines are eagerly awaited.
登革热传统上主要是一种影响儿童群体的疾病，近几十年来其负担显著增加，患有严重疾病的成年人可能变得更加常见。目前尚无有效的抗病毒药物可用于治疗登革热，支持性护理是主要的治疗手段。涵盖领域：我们对当前关于登革热严重程度分类系统以及成人严重登革热管理的文献进行了综述。特别强调了登革热中的器官损伤以及患有多种医疗问题的老年人的管理。专家评论：迫切需要寻找一种有效的抗病毒药物来治疗感染者。大龄儿童可用的登革热疫苗为减轻疾病负担带来了希望，但长期疗效和安全性尚不清楚。人们热切期待两种新候选疫苗的三期试验结果。
