Trokel S
J Cataract Refract Surg. 1989 Jul;15(4):373-83. doi: 10.1016/s0886-3350(89)80054-9.
Interest in the potential of the excimer laser for refractive surgery was generated by a series of experiments performed in IBM's T.J. Watson laboratories. The development of photoablative decomposition was applied to corneas with immediate implication for corneal refractive control. Scientific investigations demonstrated that submicron erosion ablation of material was possible without damage to remaining tissues. After refinement of the beam and analysis of thresholds, we subsequently demonstrated that healing of large ablated areas in rabbits and then primate eyes would occur without scar formation or loss of transparency. This prompted a number of commercial efforts to develop this device for both refractive and general corneal surgical applications. The early clinical investigations show that a predictable refractive change could be induced in a cornea and this change was stable over many months. Furthermore, the transparency of the cornea was unimpaired. These favorable early results have led to a number of clinical investigations of excimer laser corneal surgery including refractive keratectomy, a direct laser keratomileusis.
IBM的T.J.沃森实验室进行的一系列实验引发了人们对准分子激光用于屈光手术潜力的兴趣。光致分解技术的发展被应用于角膜，这对角膜屈光控制具有直接意义。科学研究表明，可以实现材料的亚微米级侵蚀消融，而不会对剩余组织造成损伤。在对光束进行改进并分析阈值之后，我们随后证明，兔子以及灵长类动物眼睛中大面积消融区域的愈合不会形成疤痕或丧失透明度。这促使许多商业机构致力于开发这种用于屈光和一般角膜手术应用的设备。早期临床研究表明，角膜可以产生可预测的屈光变化，并且这种变化在数月内保持稳定。此外，角膜的透明度未受损害。这些早期的良好结果引发了一系列关于准分子激光角膜手术的临床研究，包括屈光性角膜切削术，即直接激光角膜磨镶术。
