McDonald M B, Frantz J M, Klyce S D, Salmeron B, Beuerman R W, Munnerlyn C R, Clapham T N, Koons S J, Kaufman H E
Lions Eye Research Laboratories, Louisiana State University Medical Center, School of Medicine, New Orleans.
Arch Ophthalmol. 1990 Jan;108(1):40-7. doi: 10.1001/archopht.1990.01070030046026.
Photorefractive keratectomy for the correction of myopia was performed in 32 eyes of 16 green monkeys. The corneas healed satisfactorily, with normal formation of basal lamina and hemidesmosomal attachments visible in 14-week histologic specimens. No recurrent erosions were observed clinically. After a transient period of faint haze, all corneas were clear at 17 weeks and remained clear through the 1-year follow-up. In terms of accuracy, all corneas demonstrated a significant flattening compared with preoperative values, but no significant difference was seen between the groups with different intended corrections (1.5 and 3 diopters). The changes in corneal shape stabilized by 17 weeks, as measured by keratometry. The clinical results suggest that mechanical removal of the epithelium is preferable to laser ablation of the epithelium. Overall, the results demonstrate that excimer laser ablation of the corneal stroma can produce a stable diptric change in the primate cornea with good healing and long-term corneal clarity.
对16只绿猴的32只眼睛进行了准分子激光原位角膜磨镶术来矫正近视。角膜愈合良好，在14周的组织学标本中可见基底膜正常形成和半桥粒附着。临床上未观察到复发性糜烂。经过短暂的轻度 haze期后，所有角膜在17周时均清晰，并在1年的随访中保持清晰。在准确性方面，与术前值相比，所有角膜均显示出明显变平，但不同预期矫正度数（1.5和3屈光度）的组之间未观察到显著差异。通过角膜曲率计测量，角膜形状的变化在17周时稳定下来。临床结果表明，机械去除上皮优于激光消融上皮。总体而言，结果表明准分子激光消融角膜基质可在灵长类动物角膜中产生稳定的屈光变化，愈合良好且角膜长期保持清晰。
