Mutolo Maria G, Marciano Sara, Benassi Francesca, Pardini Matteo, Curatolo Paolo, Emberti Gialloreti Leonardo
*Ophthalmology Unit, NESMOS Department, Sant'Andrea Hospital, University of Rome "Sapienza," Rome, Italy; †Pediatric Neurology Unit, Department of Neuroscience, University of Rome "Tor Vergata," Rome, Italy; ‡Centre for Communication and Neurorehabilitation Research-CNAPP, Rome, Italy; §Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa, Genoa, Italy; ¶Department of Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, Genoa, Italy; and **Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Rome, Italy.
Retina. 2017 Jul;37(7):1383-1392. doi: 10.1097/IAE.0000000000001373.
To detect, describe, and classify the morphologic characteristics of astrocytic hamartomas in tuberous sclerosis complex, using both spectral-domain optical coherence tomography (OCT) and infrared images.
Ten subjects (20 eyes) with tuberous sclerosis complex underwent a complete ophthalmologic examination and multimodality imaging with spectral-domain OCT and infrared images. The imaging protocol included a 30°scan angle of the posterior pole and of the four quadrants. Line scans, detail, raster, and posterior pole patterns were used. The identified astrocytic hamartomas were described and characterized qualitatively and quantitatively.
Forty-four hamartomas were detected in 8 patients. In five cases, lesions were bilateral. Thirty of these hamartomas had not been revealed by previous ophthalmoscopy. Through multimodality imaging, it was possible to define multiple lesions with characteristic optical reflective qualities. All the 44 hamartomas were measured and morphologically characterized in terms of the type of tumor, retinal and/or vitreous involvement, calcifications, and posterior optical shadowing.
The combined imaging with spectral-domain OCT and infrared images improves the detection of hamartomas if compared with the spectral-domain OCT technique alone. Moreover, a new subtype of hamartoma is proposed to complete a previous classification based on OCT.
使用频域光学相干断层扫描（OCT）和红外图像检测、描述并分类结节性硬化症中星形细胞错构瘤的形态学特征。
10名患有结节性硬化症的受试者（20只眼）接受了全面的眼科检查，并使用频域OCT和红外图像进行多模态成像。成像方案包括对后极和四个象限进行30°扫描角的扫描。使用了线扫描、细节、光栅和后极模式。对识别出的星形细胞错构瘤进行定性和定量描述及特征分析。
在8名患者中检测到44个错构瘤。5例病变为双侧性。其中30个错构瘤此前的检眼镜检查未发现。通过多模态成像，可以确定具有特征性光学反射特性的多个病变。对所有44个错构瘤进行了测量，并根据肿瘤类型、视网膜和/或玻璃体受累情况、钙化以及后部光学阴影进行了形态学特征分析。
与单独使用频域OCT技术相比，频域OCT和红外图像的联合成像提高了错构瘤的检测率。此外，提出了一种新的错构瘤亚型，以完善之前基于OCT的分类。
