Couto C G, Boudrieau R J, Zanjani E D
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus.
J Vet Intern Med. 1989 Jul-Sep;3(3):183-5. doi: 10.1111/j.1939-1676.1989.tb03096.x.
Erythrocytosis (hematocrit, 79%) was diagnosed in an 8-year-old, neutered female, mixed-breed dog with an intranasal fibrosarcoma. Both serum and tumor erythropoietin (Ep) activities were elevated, as determined by the polycythemic exhypoxic mouse model, and the Ep activity was neutralized in that model by rabbit anti-Ep antibodies. Tumor resection normalized the hematocrit.
一只8岁已绝育的雌性混种犬被诊断患有鼻腔纤维肉瘤，同时伴有红细胞增多症（血细胞比容为79%）。通过红细胞增多症低氧小鼠模型测定，血清和肿瘤促红细胞生成素（Ep）活性均升高，并且在该模型中Ep活性可被兔抗Ep抗体中和。肿瘤切除术后血细胞比容恢复正常。
