来自贯穿叶墨香菊的萜类化合物。

Terpenoids from Melampodium perfoliatum.

作者信息

Arciniegas Amira, Pérez-Castorena Ana-L, Nieto-Camacho Antonio, Villaseñor José L, Romo de Vivar Alfonso

机构信息

Instituto de Química and ‡Instituto de Biología, Universidad Nacional Autónoma de México, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, México.

出版信息

J Nat Prod. 2016 Nov 23;79(11):2780-2787. doi: 10.1021/acs.jnatprod.6b00321. Epub 2016 Oct 27.

DOI:10.1021/acs.jnatprod.6b00321

PMID:27787995

Abstract

The phytochemical study of the aerial parts of Melampodium perfoliatum afforded six melampolides (1, 3, 5-8), a eudesmanolide (9), two diterpene lactones (10, 11), and two ent-kaurane derivatives (12, 13), together with the known melampodin (2) and polymatin A (4). The structures of the compounds were elucidated by physical data analysis and chemical reactions. Compounds 2, 4, 5, and 10 exhibited dose-dependent anti-inflammatory activity on the 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model, with ID values of 1.14, 0.56, 1.15, and 1.49 μmol/ear, respectively, compared to the reference compound indomethacin (0.24 μmol/ear).

摘要

对贯穿叶牛膝地上部分的植物化学研究得到了六种牛膝内酯（1、3、5 - 8）、一种桉叶烷型倍半萜内酯（9）、两种二萜内酯（10、11）以及两种对映 - 贝壳杉烷衍生物（12、13），同时还得到了已知的牛膝定（2）和多马亭A（4）。通过物理数据分析和化学反应阐明了这些化合物的结构。化合物2、4、5和10在12 - O - 十四酰佛波醇 - 13 - 乙酸酯诱导的耳肿胀模型上呈现出剂量依赖性抗炎活性，与参考化合物吲哚美辛（0.24 μmol/耳）相比，其ID值分别为1.14、0.56、1.15和1.49 μmol/耳。