探索阿尔及利亚蚤草属植物的生物活性萜类成分：紫菀内酯的对映-系列

Exploring the Bioactive Terpenoid Content of an Algerian Plant of the Genus Pulicaria: The ent-Series of Asteriscunolides.

作者信息

Boumaraf Manel, Carbone Marianna, Ciavatta M Letizia, Benyahia Samira, Ameddah Souad, Menad Ahmed, Benayache Samir, Benayache Fadila, Gavagnin Margherita

机构信息

Istituto di Chimica Biomolecolare, CNR , Via Campi Flegrei 34, 80078 Pozzuoli (Naples), Italy.

Unité de Recherche: Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Frères Mentouri, Constantine , Route de Aïn El Bey, 25 000 Constantine, Algérie.

出版信息

J Nat Prod. 2017 Jan 27;80(1):82-89. doi: 10.1021/acs.jnatprod.6b00717. Epub 2016 Dec 29.

DOI:10.1021/acs.jnatprod.6b00717

PMID:28032767

Abstract

Chemical analysis of the chloroform extract of the aerial parts of the Algerian plant Pulicaria undulata exhibiting anti-inflammatory activity resulted in the isolation of 10 new humulene sesquiterpenoids, 1-10, belonging to the asteriscunolide family of compounds. The structure and relative configuration have been defined by NMR data, whereas the absolute configuration has been established by ECD analysis. Compounds 1-10 include enantiomers of the known asteriscunolides A-D and tetrahydroasteriscunolide previously reported from the genera Asteriscus and Nauplius. Compounds 1 and 10 showed in vitro anti-inflammatory activity by inhibiting heat-induced albumin denaturation with IC values of 23.76 and 220.42 μM.

摘要

对具有抗炎活性的阿尔及利亚植物波叶旋覆花地上部分的氯仿提取物进行化学分析，从中分离出10种新的葎草烯倍半萜类化合物1 - 10，它们属于星芒内酯类化合物。其结构和相对构型已通过核磁共振数据确定，而绝对构型则通过电子圆二色光谱分析确定。化合物1 - 10包括之前从星芒属和无节幼体属报道过的已知星芒内酯A - D和四氢星芒内酯的对映体。化合物1和10通过抑制热诱导的白蛋白变性表现出体外抗炎活性，其半数抑制浓度值分别为23.76和220.42 μM。