Morgat Anne, Lombardot Thierry, Axelsen Kristian B, Aimo Lucila, Niknejad Anne, Hyka-Nouspikel Nevila, Coudert Elisabeth, Pozzato Monica, Pagni Marco, Moretti Sébastien, Rosanoff Steven, Onwubiko Joseph, Bougueleret Lydie, Xenarios Ioannis, Redaschi Nicole, Bridge Alan
Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland
ERABLE team, INRIA Grenoble Rhône-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France.
Nucleic Acids Res. 2017 Jan 4;45(D1):D415-D418. doi: 10.1093/nar/gkw990. Epub 2016 Oct 26.
Rhea (http://www.rhea-db.org) is a comprehensive and non-redundant resource of expert-curated biochemical reactions designed for the functional annotation of enzymes and the description of metabolic networks. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions, using entities from the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules. Here we describe developments in Rhea since our last report in the database issue of Nucleic Acids Research. These include the first implementation of a simple hierarchical classification of reactions, improved coverage of the IUBMB Enzyme Nomenclature list and additional reactions through continuing expert curation, and the development of a new website to serve this improved dataset.
