Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK.
Nucleic Acids Res. 2012 Jan;40(Database issue):D754-60. doi: 10.1093/nar/gkr1126. Epub 2011 Dec 1.
Rhea (http://www.ebi.ac.uk/rhea) is a comprehensive resource of expert-curated biochemical reactions. Rhea provides a non-redundant set of chemical transformations for use in a broad spectrum of applications, including metabolic network reconstruction and pathway inference. Rhea includes enzyme-catalyzed reactions (covering the IUBMB Enzyme Nomenclature list), transport reactions and spontaneously occurring reactions. Rhea reactions are described using chemical species from the Chemical Entities of Biological Interest ontology (ChEBI) and are stoichiometrically balanced for mass and charge. They are extensively manually curated with links to source literature and other public resources on metabolism including enzyme and pathway databases. This cross-referencing facilitates the mapping and reconciliation of common reactions and compounds between distinct resources, which is a common first step in the reconstruction of genome scale metabolic networks and models.
Rhea（http://www.ebi.ac.uk/rhea）是一个全面的专家 curated 生化反应资源。Rhea 提供了一套非冗余的化学转化，可用于广泛的应用，包括代谢网络重建和途径推断。Rhea 包括酶促反应（涵盖 IUBMB 酶命名法列表）、转运反应和自发发生的反应。Rhea 反应使用来自生物化学实体本体论（ChEBI）的化学物质来描述，并在质量和电荷上进行了化学计量平衡。它们经过广泛的人工精心编辑，并与代谢相关的文献和其他公共资源（包括酶和途径数据库）链接。这种交叉引用促进了不同资源之间常见反应和化合物的映射和协调，这是重建基因组尺度代谢网络和模型的常见第一步。
