Kim Seong Han, Yang Seo Yeon, You Jihong, Lee Sang Bae, You Jin, Chang Yoon Soo, Kim Hyung Jung, Ahn Chul Min, Byun Min Kwang, Park Hye Jung, Park Jung-Won
Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Department of Internal Medicine, Kunkuk University School of Medicine, Seoul, Korea.
Tuberc Respir Dis (Seoul). 2016 Oct;79(4):295-301. doi: 10.4046/trd.2016.79.4.295. Epub 2016 Oct 5.
Specific immunoglobulin E (IgE) sensitization to staphylococcal enterotoxin (SE) has been recently considered to be related to allergic disease, including asthma. Despite studies on specific IgE (sIgE) to SE and its relationship to asthma diagnosis and severity, the association of sIgE to SE with airway hyperresponsiveness (AHR) remains unclear.
We enrolled 81 asthma patients admitted to the Severance Hospital in Korea from March 1, 2013, to February 28, 2015 and retrospectively reviewed the electronic medical records of the enrolled subjects. The serum levels of sIgE to SE (A/B) of all subjects was measured using the ImmunoCAP 250 (Phadia) system with SE-sIgE positive defined as >0.10 kU/mL.
The SE-sIgE level was not significantly correlated with asthma severity (forced expiratory volume in 1 second [FEV], FEV/forced vital capacity, sputum eosinophils, and serum eosinophils), whereas the SE-sIgE level in patients with positive AHR (mean±standard error of the mean, 0.606±0.273 kU/mL) was significantly higher than that in patients with negative AHR (0.062±0.015 kU/mL, p=0.034). In regression analysis, SE sensitization (sIgE to SE ≥0.010 kU/mL) was a significant risk factor for AHR, after adjustment for age, sex, FEV, and sputum eosinophils (odds ratio, 7.090; 95% confidence interval, 1.180-42.600; p=0.032). Prevalence of SE sensitization was higher in patients with allergic rhinitis and non-atopic asthma patients, as compared to patients without allergic rhinitis and atopic asthma patients, respectively, but without statistical significance.
SE sensitization is significantly associated with AHR.
近期研究认为，对葡萄球菌肠毒素（SE）的特异性免疫球蛋白E（IgE）致敏与包括哮喘在内的过敏性疾病相关。尽管已有关于SE特异性IgE（sIgE）及其与哮喘诊断和严重程度关系的研究，但sIgE与气道高反应性（AHR）之间的关联仍不明确。
我们纳入了2013年3月1日至2015年2月28日在韩国Severance医院住院的81例哮喘患者，并回顾性分析了这些受试者的电子病历。使用ImmunoCAP 250（Phadia）系统检测所有受试者血清中SE的sIgE水平（A/B），SE-sIgE阳性定义为>0.10 kU/mL。
SE-sIgE水平与哮喘严重程度（第1秒用力呼气容积[FEV]、FEV/用力肺活量、痰液嗜酸性粒细胞和血清嗜酸性粒细胞）无显著相关性，而AHR阳性患者的SE-sIgE水平（平均值±平均标准误，0.606±0.273 kU/mL）显著高于AHR阴性患者（0.062±0.015 kU/mL，p=0.034）。在回归分析中，校正年龄、性别、FEV和痰液嗜酸性粒细胞后，SE致敏（sIgE至SE≥0.010 kU/mL）是AHR的显著危险因素（比值比，7.090；95%置信区间，1.180 - 42.600；p=0.032）。与无过敏性鼻炎患者和特应性哮喘患者相比，过敏性鼻炎患者和非特应性哮喘患者的SE致敏率分别更高，但无统计学意义。
SE致敏与AHR显著相关。
