Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland.
First Laboratory of Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Respir Res. 2023 Sep 22;24(1):225. doi: 10.1186/s12931-023-02520-4.
Sensitization to Staphylococcus aureus enterotoxins A (SEA) and B (SEB) has been associated with asthma severity, exacerbations, and disease control. Our study aimed to investigate if there are differences in serum SEA-IgE and SEB-IgE levels between patients with chronic obstructive pulmonary disease (COPD), asthma, and controls, and to assess the association between SE sensitization and COPD clinical parameters and Th2 inflammation biomarkers in two well-defined COPD cohorts. Our findings suggest that COPD patients do not exhibit higher SEA and SEB sensitization compared to asthma patients and controls. However, in COPD patients, the presence of atopy and allergy is associated with positivity for SEA-IgE and SEB-IgE. Consequently, these allergens may aid in identifying atopic or allergic subgroups within the COPD population, but they are not directly associated with the diagnosis of COPD, elevated circulating blood eosinophils, or fractional exhaled nitric oxide (FENO) levels.
金黄色葡萄球菌肠毒素 A（SEA）和 B（SEB）的致敏与哮喘严重程度、加重和疾病控制有关。我们的研究旨在调查慢性阻塞性肺疾病（COPD）、哮喘和对照组患者之间血清 SEA-IgE 和 SEB-IgE 水平是否存在差异，并评估 SE 致敏与 COPD 临床参数和两个明确 COPD 队列中 Th2 炎症生物标志物之间的关系。我们的研究结果表明，与哮喘患者和对照组相比，COPD 患者并没有表现出更高的 SEA 和 SEB 致敏。然而，在 COPD 患者中，特应性和过敏与 SEA-IgE 和 SEB-IgE 的阳性有关。因此，这些过敏原可能有助于确定 COPD 人群中的特应性或过敏亚组，但它们与 COPD 的诊断、循环血液嗜酸性粒细胞升高或呼出气一氧化氮分数（FENO）水平升高并无直接关系。
