Park Hye Jung, Kim Eun Jin, Yoon Dankyu, Lee Jeom Kyu, Chang Woo Sung, Lim Yoen Mi, Park Jung Won, Lee Joo Shil
Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Center for Diseases Control and Prevention, Osong, Korea.
Allergy Asthma Immunol Res. 2017 Jul;9(4):329-339. doi: 10.4168/aair.2017.9.4.329.
The prevalence of allergic diseases is known to be associated with both demographic and environmental factors. Herein, we aimed to determine significant factors associated with the prevalence of allergic diseases and with total immunoglobulin E (tIgE) and specific immunoglobulin E (sIgE) levels in Korea.
We analyzed unweighted data collected by the 2010 Korea National Health and Nutrition Examination Survey for 2,342 subjects who underwent serum tests for tIgE and sIgE to Dermatophagoides farinae, dog, and Blattella germanica, representing a sample of 16,003,645 citizens, by considering the sample weight and stratification.
The overall prevalence of self-reported allergic diseases was 37.6%. The prevalence rates of allergic rhinitis and atopic dermatitis decreased with age, whereas the asthma prevalence was not affected by the age of the subjects. When analyzed according to the type of allergic diseases, the prevalence of self-reported allergic disease was significantly associated with various factors (e.g. age, occupation, living in urban areas, and depression). The tIgE level decreased with age, but later increased. Elevation of tIgE was significantly associated with male sex, type of occupation, obesity, and smoking status. However, the risk factors for the increased sIgE levels to each allergen were quite different. Sensitization to D. farinae was more likely in young subjects, whereas the prevalence of sensitization to B. germanica was significantly higher in subjects with male sex, residing in a house (houses), and with glucose intolerance. Finally, young age and the smoking status were significantly associated with sensitization to dog.
Various demographic and environmental factors were significantly associated with the prevalence of self-reported allergic diseases and the levels of tIgE and sIgE to D. farinae, B. germanica, and dog in Korea.
已知过敏性疾病的患病率与人口统计学和环境因素相关。在此，我们旨在确定与韩国过敏性疾病患病率以及总免疫球蛋白E（tIgE）和特异性免疫球蛋白E（sIgE）水平相关的重要因素。
我们分析了2010年韩国国家健康与营养检查调查收集的未加权数据，这些数据来自2342名接受了针对粉尘螨、狗和德国小蠊的tIgE和sIgE血清检测的受试者，通过考虑样本权重和分层，该样本代表了16003645名公民。
自我报告的过敏性疾病总体患病率为37.6%。过敏性鼻炎和特应性皮炎的患病率随年龄下降，而哮喘患病率不受受试者年龄影响。根据过敏性疾病类型进行分析时，自我报告的过敏性疾病患病率与多种因素（如年龄、职业、居住在城市地区和抑郁）显著相关。tIgE水平随年龄下降，但随后上升。tIgE升高与男性、职业类型、肥胖和吸烟状况显著相关。然而，每种变应原sIgE水平升高的危险因素差异很大。对粉尘螨致敏在年轻受试者中更常见，而对德国小蠊致敏的患病率在男性、居住在房屋中的受试者以及糖耐量异常的受试者中显著更高。最后，年轻和吸烟状况与对狗致敏显著相关。
在韩国，各种人口统计学和环境因素与自我报告的过敏性疾病患病率以及对粉尘螨、德国小蠊和狗的tIgE和sIgE水平显著相关。
