Dhibar Deba Prasad, Sharma Yash Paul, Bhadada Sanjay Kumar, Sachdeva Naresh, Sahu Kamal Kant
Senior Resident, Department of Internal Medicine, PGIMER , Chandigarh, India .
Professor & Head, Department of Cardiology, PGIMER , Chandigarh, India .
J Clin Diagn Res. 2016 Sep;10(9):OC24-OC28. doi: 10.7860/JCDR/2016/22718.8526. Epub 2016 Sep 1.
Coronary Artery Disease (CAD) is a major global health problem. Recent studies demonstrated that lower vitamin D level (<30ng/ml) is associated with higher blood pressure and directly or indirectly with CAD, due to vascular endothelial damage. However the results are inconsistent.
To find the association of vitamin D deficiency with CAD.
In this cross-sectional observational study, serum vitamin D level was measured in 315 patients who underwent coronary angiography.
The mean (±SD) vitamin D was 13.40ng/ml (±10.40). However, the patients with normal coronary artery had much lower mean vitamin D (11.30ng/ml±9.50) as compared to the patients with CAD (14.10ng/ml±10.70). The mean (±SD) vitamin D levels were 19.00ng/ml (±16.50), 14.10ng/ml (±11.10) and 13.20ng/ml (±8.80) in patients with CAD with 50%-70%, >70%-90% and >90% stenosis respectively (p= 0.46) and 15.20ng/ml (±13.00), 15.50ng/ml (±11.30) and 11.80ng/ml (±7.00) in patients with CAD with single, double and triple vessels disease respectively (p= 0.14). The frequency of vitamin D deficiency were 66.70%, 83.20 % and 83.10% in patients with CAD with 50% -70%, >70%-90% and >90% stenosis respectively and 81.40%, 80.00% and 83.50% in patients with single, double and triple vessel disease respectively, as compared to 89.30% in patients with normal coronary artery (p= 0.41 and 0.075). So, all the study groups of CAD had low serum vitamin D level and high frequency of vitamin D deficiency, which was statistically insignificant.
Prevalence of vitamin D deficiency is very high in CAD, but it does not correlate with the angiographic severity of CAD.
冠状动脉疾病（CAD）是一个重大的全球健康问题。最近的研究表明，较低的维生素D水平（<30ng/ml）与较高的血压相关，并且由于血管内皮损伤，与CAD直接或间接相关。然而，结果并不一致。
探讨维生素D缺乏与CAD的关联。
在这项横断面观察性研究中，对315例行冠状动脉造影的患者测定血清维生素D水平。
维生素D的平均（±标准差）水平为13.40ng/ml（±10.40）。然而，冠状动脉正常的患者维生素D平均水平（11.30ng/ml±9.50）远低于CAD患者（14.10ng/ml±10.70）。CAD患者中，狭窄程度为50%-70%、>70%-90%和>90%时，维生素D平均（±标准差）水平分别为19.00ng/ml（±16.50）、14.10ng/ml（±11.10）和13.20ng/ml（±8.80）（p=0.46）；单支、双支和三支血管病变的CAD患者中，维生素D平均（±标准差）水平分别为15.20ng/ml（±13.00）、15.50ng/ml（±11.30）和11.80ng/ml（±7.00）（p=0.14）。CAD患者中，狭窄程度为50%-70%、>70%-90%和>90%时，维生素D缺乏的发生率分别为66.70%、83.20%和83.10%；单支、双支和三支血管病变的CAD患者中，维生素D缺乏的发生率分别为81.40%、80.00%和83.50%，而冠状动脉正常的患者中这一比例为89.30%（p=0.41和0.075）。因此，所有CAD研究组的血清维生素D水平均较低，维生素D缺乏的发生率较高，但差异无统计学意义。
CAD患者中维生素D缺乏的患病率非常高，但与CAD的血管造影严重程度无关。
