Thampy Anupa, Pais Christopher C
Postgraduate Student, Department of Internal Medicine, Kasturba Medical College , Mangaluru, Karnataka, India .
Professor, Department of Internal Medicine, Kasturba Medical College , Mangaluru, Karnataka, India .
J Clin Diagn Res. 2016 Sep;10(9):OC29-OC31. doi: 10.7860/JCDR/2016/19690.8533. Epub 2016 Sep 1.
Cardiovascular and cerebrovascular diseases are leading causes of morbidity and mortality worldwide. Stroke accounts for the second leading cause of death, about 11.13% of total deaths worldwide. Microalbuminuria is known to be associated with increased risk of mortality in ischaemic stroke patients. But there have been no studies to assess whether microalbuminuria affects the early clinical outcome of patients with acute ischaemic stroke.
This study aims to investigate whether microalbuminuria affects the early clinical outcome of patients with acute ischaemic stroke.
This is a prospective study of patients with ischaemic stroke (who presented within 24 hours of symptom onset) who were consecutively admitted in three tertiary care centres during the time period from November 2013 to June 2015. Early clinical outcomes in patients were assessed by investigating the presence of Early Neurological Deterioration (END) using the National Institute of Health Stroke Scale. Urine albumin creatinine ratio was divided into two categories - Normal (less than 30mg/g of creatinine) or Urine Microalbuminuria (30-300 mg/g of creatinine).
Total 42 out of 70 patients (60%) were found to have microalbuminuria. In multivariate logistic regression analysis, microalbuminuria was found to be independently associated with END in patients with acute ischaemic stroke (p=0.044).
In the early periods following acute ischaemic stroke, patients with microalbuminuria have worse clinical outcome.
心血管疾病和脑血管疾病是全球发病和死亡的主要原因。中风是第二大死因，约占全球总死亡人数的11.13%。已知微量白蛋白尿与缺血性中风患者的死亡风险增加有关。但尚无研究评估微量白蛋白尿是否会影响急性缺血性中风患者的早期临床结局。
本研究旨在调查微量白蛋白尿是否会影响急性缺血性中风患者的早期临床结局。
这是一项对缺血性中风患者（症状发作后24小时内就诊）的前瞻性研究，这些患者于2013年11月至2015年6月期间在三个三级医疗中心连续入院。通过使用美国国立卫生研究院卒中量表调查早期神经功能恶化（END）的存在情况来评估患者的早期临床结局。尿白蛋白肌酐比值分为两类——正常（肌酐低于30mg/g）或微量白蛋白尿（肌酐为30 - 300mg/g）。
70例患者中有42例（60%）被发现有微量白蛋白尿。在多因素逻辑回归分析中，发现微量白蛋白尿与急性缺血性中风患者的END独立相关（p = 0.044）。
在急性缺血性中风后的早期，微量白蛋白尿患者的临床结局更差。
