Xu Kuo, Feng Zi-Ming, Yang Ya-Nan, Jiang Jian-Shuang, Zhang Pei-Cheng
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050 , China.
J Asian Nat Prod Res. 2017 Feb;19(2):121-127. doi: 10.1080/10286020.2016.1247811. Epub 2016 Oct 28.
An ongoing phytochemical investigation of the rhizomes of Atractylodes lancea resulted in the isolation of four new C-type polyacetylene glycosides (1-4). Their structures were elucidated on the basis of extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of compounds 2-4 were determined by comparing the specific rotations of their aglycones. Notably, compounds 2 and 3 exhibited significant hepatoprotective activities against APAP-induced HepG2 cell injury at a concentration of 10 μM. Compounds 2 and 3 showed weak anti-inflammatory effects on LPS-induced NO production in microglia BV2 cells at a concentration of 10 μM.
对白术根茎进行的一项正在进行的植物化学研究，分离出了四种新的C型聚乙炔糖苷（1-4）。基于广泛的光谱数据（紫外、红外、一维和二维核磁共振以及高分辨电喷雾电离质谱）阐明了它们的结构。通过比较化合物2-4苷元的比旋光度确定了其绝对构型。值得注意的是，化合物2和3在浓度为10 μM时，对乙酰氨基酚诱导的HepG2细胞损伤表现出显著的肝保护活性。化合物2和3在浓度为10 μM时，对小胶质细胞BV2细胞中脂多糖诱导的一氧化氮产生显示出微弱的抗炎作用。
