School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Nat Prod Res. 2020 Apr;34(8):1138-1145. doi: 10.1080/14786419.2018.1553170. Epub 2019 Jan 8.
Six sesquiterpenoids and four lignans (-) were isolated from the -BuOH extract of the rhizomes of . Among them, the new sesquiterpenoid glycoside named (4 , 5, 7)-hinesolone-11---ᴅ-glucopyranoside (), along with three known compounds (-) were first obtained from this genus. All the isolates were elucidated by spectroscopic analyses and chemical methods, and the absolute configurations were assigned by electronic circular dichroism spectroscopy technique. In addition, the cytotoxic bioassay of compound was evaluated and results showed it had no significant antitumor activity against human cancer cell lines MCF-7, HepG-2 and Hela.
从 的根茎 -BuOH 提取物中分离得到了六种倍半萜和四种木脂素（-）。其中，新的倍半萜苷命名为（4,5,7）-hinesolone-11---ᴅ-吡喃葡萄糖苷（），以及三种已知化合物（-），首次从该属中获得。所有分离物均通过光谱分析和化学方法阐明，并用电子圆二色光谱技术确定了绝对构型。此外，还评估了化合物 的细胞毒性生物测定，结果表明它对人癌细胞系 MCF-7、HepG-2 和 Hela 没有显著的抗肿瘤活性。
