Feng Zi-Ming, Xu Kuo, Wang Wei, Du Ning, Zhang Jing-Hua, Yang Ya-Nan, Jiang Jian-Shuang, Zhang Pei-Cheng
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050 , China.
b Beijing Centre for Physical and Chemical Analysis , Beijing 100089 , China.
J Asian Nat Prod Res. 2018 Jun;20(6):531-537. doi: 10.1080/10286020.2018.1458841. Epub 2018 Apr 3.
Phytochemical investigation on the rhizomes of Atractylodes lancea led to the isolation of two new thiophene polyacetylene glycosides (1 and 2) and six known compounds (3-8). Their structures were elucidated based on the extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of new compounds were established by calculated and experimental circular dichroism. All the compounds were assessed on the lipopolysaccharide-induced NO production in BV2 cells and compounds 3, 7, and 8 showed moderate inhibitory activities.
对茅苍术根茎进行植物化学研究，分离得到两种新的噻吩聚乙炔糖苷（1和2）以及六种已知化合物（3 - 8）。基于广泛的光谱数据（紫外、红外、一维和二维核磁共振以及高分辨电喷雾电离质谱）阐明了它们的结构。通过计算和实验圆二色性确定了新化合物的绝对构型。对所有化合物在BV2细胞中脂多糖诱导的一氧化氮产生情况进行了评估，化合物3、7和8表现出中等抑制活性。
