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斑马鱼（Danio rerio）钙代谢的调控

The Control of Calcium Metabolism in Zebrafish (Danio rerio).

作者信息

Lin Chia-Hao, Hwang Pung-Pung

机构信息

National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan.

Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.

出版信息

Int J Mol Sci. 2016 Oct 26;17(11):1783. doi: 10.3390/ijms17111783.

DOI:10.3390/ijms17111783
PMID:27792163
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5133784/
Abstract

Zebrafish is an emerging model for the research of body fluid ionic homeostasis. In this review, we focus on current progress on the regulation of Ca uptake in the context of Ca sensing and hormonal regulation in zebrafish. Na⁺-K⁺-ATPase-rich cells (NaRCs), the specialized ionocytes in the embryonic skin and adult gills, play a dominant role in Ca uptake in zebrafish. Transepithelial Ca transport in NaRC, through apical epithelial Ca channels (ECaC), basolateral plasma membrane Ca-ATPase (PMCA), and Na⁺/Ca exchanger (NCX), is analogous to mammalian renal and intestinal Ca-absorption cells. Several hormones were demonstrated to differentially regulate Ca uptake through modulating the expression of Ca transporters and/or the proliferation/differentiation of NaRC in zebrafish. In addition, the counterbalance among these hormones is associated with the maintenance of body fluid Ca homeostasis. Calcium-sensing receptor (CaSR) is expressed in several hormone-secreting tissues in zebrafish, and activated CaSR differentially controls calciotropic hormones. The major principles of Ca transport and the hormonal control appear to be conserved from zebrafish to other vertebrates including mammals. The new knowledge gained from zebrafish studies provides new insights into the related issues in vertebrates.

摘要

斑马鱼是一种新兴的用于研究体液离子稳态的模式生物。在这篇综述中，我们聚焦于斑马鱼在钙感知和激素调节背景下钙摄取调节的当前进展。富含Na⁺-K⁺-ATP酶的细胞（NaRCs），即胚胎皮肤和成年鳃中的特化离子细胞，在斑马鱼的钙摄取中起主导作用。NaRC中的跨上皮钙转运，通过顶端上皮钙通道（ECaC）、基底外侧质膜钙ATP酶（PMCA）和Na⁺/Ca交换体（NCX），类似于哺乳动物的肾和肠钙吸收细胞。已证明几种激素通过调节钙转运蛋白的表达和/或斑马鱼中NaRC的增殖/分化来差异调节钙摄取。此外，这些激素之间的平衡与体液钙稳态的维持有关。钙敏感受体（CaSR）在斑马鱼的几种激素分泌组织中表达，激活的CaSR差异控制钙调节激素。从斑马鱼研究中获得的新知识为脊椎动物中的相关问题提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5562/5133784/1d5bcdf5d162/ijms-17-01783-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5562/5133784/73917a638ffa/ijms-17-01783-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5562/5133784/702623872bdb/ijms-17-01783-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5562/5133784/ff1590feb71d/ijms-17-01783-g003.jpg
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