Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
J Bone Miner Res. 2022 Oct;37(10):1823-1842. doi: 10.1002/jbmr.4678. Epub 2022 Sep 14.
In mammals, hematopoiesis migrates to the bone marrow during embryogenesis coincident with the appearance of mineralized bone, where hematopoietic stem cells (HSCs) and their progeny are maintained by the surrounding microenvironment or niche, and sustain the entirety of the hematopoietic system. Genetic manipulation of niche factors and advances in cell lineage tracing techniques have implicated cells of both hematopoietic and nonhematopoietic origin as important regulators of hematopoiesis in health and disease. Among them, cells of the osteoblast lineage, from stromal skeletal stem cells to matrix-embedded osteocytes, are vital niche residents with varying capacities for hematopoietic support depending on stage of differentiation. Here, we review populations of osteoblasts at differing stages of differentiation and summarize the current understanding of the role of the osteoblast lineage in supporting hematopoiesis. © 2022 American Society for Bone and Mineral Research (ASBMR).
在哺乳动物中，造血发生在胚胎发生期间迁移到骨髓，与矿化骨的出现同时发生，造血干细胞 (HSCs) 和它们的后代由周围的微环境或龛维持，并维持整个造血系统。龛因子的遗传操作和谱系追踪技术的进步表明，造血和非造血来源的细胞都是健康和疾病中造血的重要调节因子。其中，成骨细胞谱系的细胞，从基质骨骼干细胞到基质嵌入的成骨细胞，是重要的龛位居民，根据分化阶段的不同，具有不同的造血支持能力。在这里，我们回顾了不同分化阶段的成骨细胞群体，并总结了成骨细胞谱系在支持造血中的作用的现有认识。© 2022 美国骨骼和矿物质研究协会 (ASBMR)。
