Laberg J C, Löberg T
Hjellestad Clinic, Norway.
J Stud Alcohol. 1989 Sep;50(5):448-55. doi: 10.15288/jsa.1989.50.448.
Interactive effects of expectancy and alcohol dose on CNS functioning were examined in subjects differing in degree of dependence on alcohol, using the balanced placebo design. Male subjects (N = 30), 10 severely-, 10 moderately- and 10 nondependent on alcohol, were tested with the Klove-Matthews Motor Steadiness Battery before and after drinking. The administered alcohol dose yielded .07 mg/dl mean blood alcohol level. Expectations about alcohol resulted in impaired sensorimotor coordination in severely dependent alcoholics, as compared to expectations of soft drinks. Moderately dependent subjects showed an opposite response pattern. Such expectancy factors may counteract neuropharmacological tolerance effects, neutralizing real tolerance effects on moderate doses of alcohol for severely dependent alcoholics. High tolerance also makes larger quantities necessary, leading to increased consumption to obtain the same effect.
采用平衡安慰剂设计，在对酒精依赖程度不同的受试者中研究了预期和酒精剂量对中枢神经系统功能的交互作用。男性受试者（N = 30），其中10名严重酒精依赖者、10名中度酒精依赖者和10名非酒精依赖者，在饮酒前后用克洛弗 - 马修斯运动稳定性测试组合进行测试。所给予的酒精剂量使平均血液酒精水平达到0.07mg/dl。与预期饮用软饮料相比，对酒精的预期导致严重酒精依赖者的感觉运动协调能力受损。中度酒精依赖的受试者表现出相反的反应模式。这种预期因素可能抵消神经药理学耐受性效应，对于严重酒精依赖者而言，可中和中等剂量酒精的实际耐受性效应。高耐受性也使得需要更大的饮酒量，导致为获得相同效果而饮酒量增加。
