小鼠胚胎癌细胞与其分化衍生物之间的代谢合作。
Metabolic cooperation between mouse embryonal carcinoma cells and their differentiated derivatives.
作者信息
Nicolas J F, Jakob H, Jacob F
出版信息
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3292-6. doi: 10.1073/pnas.75.7.3292.
Abstract
Metabolic cooperation has been used as an index of intercellular communication between mouse embryonal carcinoma (EC) and other cell types. EC cells do not cooperate with differentiated cells of various properties or origins. In contrast they cooperate with cells of all other EC lines tested, including a human teratocarcinoma line, but with different efficiencies. This might reflect differences either in cell-cell interactions or in the formation of gap junctions. During in vitro differentiation, EC cells appear to remain isolated from differentiated cell types.
摘要
代谢合作已被用作小鼠胚胎癌（EC）细胞与其他细胞类型之间细胞间通讯的指标。EC细胞不与具有各种特性或来源的分化细胞合作。相反，它们与所有其他测试的EC细胞系的细胞合作，包括一个人畸胎瘤细胞系，但效率不同。这可能反映了细胞间相互作用或间隙连接形成方面的差异。在体外分化过程中，EC细胞似乎与分化细胞类型保持隔离。
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