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中国中老年人群中生育状况与肥胖模式之间的关联:同济-东风队列研究的横断面分析

Association between parity and obesity patterns in a middle-aged and older Chinese population: a cross-sectional analysis in the Tongji-Dongfeng cohort study.

作者信息

Li Wending, Wang Yi, Shen Lijun, Song Lulu, Li Hui, Liu Bingqing, Yuan Jing, Wang Youjie

机构信息

School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hangkong Road 13, Wuhan, 430030 China.

School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Hangkong Road 13, Wuhan, 430030 China ; Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

出版信息

Nutr Metab (Lond). 2016 Oct 26;13:72. doi: 10.1186/s12986-016-0133-7. eCollection 2016.

Abstract

BACKGROUND

Higher parity has been implicated as a risk factor for obesity of women. The objective of the study was to examine whether parity was associated with general obesity or abdominal obesity, or both, among middle-aged and older Chinese women.

METHODS

A total of 12,829 Chinese women (mean age: 64.8 years) with at least one live birth were selected from the Dongfeng-Tongji Cohort Study (phase II). We used body mass index to assess general obesity, and waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and waist circumference (WC) to assess abdominal obesity. We used multivariate linear and logistic regression models to investigate the association between parity and obesity.

RESULTS

The values of all four obesity measures increased with the greater number of live births ( for trend <0.001). After adjustment for potential confounders, women with four or more children had 1.72 times (95 % confidence interval [CI], 1.41-2.10) higher risk of general obesity, and 1.93 (95 % CI, 1.57-2.37), 2.09 (95 % CI, 1.65-3.64) and 1.58 (95 % CI, 1.28-1.94) times risk of abdominal obesity assessed by WHR, WHtR and WC, respectively. Furthermore, we observed an ascending gradient between parity and the three abdominal obesity measures.

CONCLUSIONS

Parity was positively associated with risk of obesity, especially abdominal obesity, in the long term among Chinese women.

摘要

背景

较高的生育次数被认为是女性肥胖的一个风险因素。本研究的目的是探讨生育次数与中国中老年女性的全身肥胖或腹型肥胖,或两者是否相关。

方法

从东风-同济队列研究(二期)中选取了12829名至少有一次活产经历的中国女性(平均年龄:64.8岁)。我们使用体重指数评估全身肥胖,使用腰臀比(WHR)、腰高比(WHtR)和腰围(WC)评估腹型肥胖。我们使用多变量线性和逻辑回归模型来研究生育次数与肥胖之间的关联。

结果

所有四种肥胖指标的值都随着活产次数的增加而升高(趋势P<0.001)。在对潜在混杂因素进行调整后,有四个或更多孩子的女性发生全身肥胖的风险高1.72倍(95%置信区间[CI],1.41-2.10),通过WHR、WHtR和WC评估的腹型肥胖风险分别高1.93倍(95%CI,1.57-2.37)、2.09倍(95%CI,1.65-3.64)和1.58倍(95%CI,1.28-1.94)。此外,我们观察到生育次数与三种腹型肥胖指标之间存在上升梯度。

结论

在中国女性中,从长期来看,生育次数与肥胖风险呈正相关,尤其是腹型肥胖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/032b/5081958/5640dd7f2d15/12986_2016_133_Fig1_HTML.jpg

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