Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle road, Qinhuai District, Nanjing, Jiangsu, 210008, China.
BMC Womens Health. 2024 Apr 5;24(1):222. doi: 10.1186/s12905-024-03055-6.
The evidence regarding the association of reproductive factors with cardiovascular diseases (CVDs) is limited.
To investigate the relationship of reproductive factors with the risk of CVDs, as well as all-cause and cardiovascular mortality.
This study included 16,404 adults with reproductive factors from the National Health and Nutrition Examination Survey (NHANES) and followed up until 31 December 2019. Logistic models and restricted cubic spline models were used to assess the association of reproductive factors with CVDs. COX proportional hazards models and restricted cubic spline models, with adjustment for potential confounding, were employed to analyze the relation between reproductive factors and cardiovascular and all-cause death.
There is a nonlinear relationship between age at menarche and CVDs. Age at menopause ≤ 11(OR 1.36, 95% CI 1.10-1.69) was associated with an increased risk of CVDs compared to ages 12-13 years. Age at Menopause ≤ 44 (OR 1.69, 95% CI 1.40-2.03) was associated with increased CVDs compared to age 35-49 years. Number of pregnancies ≥ 5(OR 1.26, 95% CI 1.02-1.55) was associated with an increased risk of CVDs compared to one pregnancy. In continuous variable COX regression models, a later age at menopause (HR 0.98, 95% CI 0.97-0.99) and a longer reproductive lifespan (HR 0.98, 95% CI 0.97-0.99) were associated with a decreased risk of all-cause death. A later age at menopause (HR 0.98, 95% CI 0.97-0.99) and a longer reproductive lifespan (HR 0.98, 95% CI 0.97-0.99) were associated with a decreased risk of cardiac death.
Female reproductive factors are significant risk factors for CVDs American women.
关于生殖因素与心血管疾病（CVDs）之间关联的证据有限。
研究生殖因素与 CVDs 风险以及全因和心血管死亡率之间的关系。
本研究纳入了来自国家健康和营养检查调查（NHANES）的 16404 名具有生殖因素的成年人，并随访至 2019 年 12 月 31 日。使用逻辑模型和限制性三次样条模型评估生殖因素与 CVDs 之间的关联。使用 COX 比例风险模型和限制性三次样条模型，并进行潜在混杂因素的调整，分析生殖因素与心血管和全因死亡之间的关系。
初潮年龄与 CVDs 之间存在非线性关系。与 12-13 岁年龄组相比，初潮年龄≤11 岁（OR 1.36，95%CI 1.10-1.69）与 CVDs 风险增加相关。与 35-49 岁年龄组相比，绝经年龄≤44 岁（OR 1.69，95%CI 1.40-2.03）与 CVDs 风险增加相关。与单胎妊娠相比，≥5 次妊娠（OR 1.26，95%CI 1.02-1.55）与 CVDs 风险增加相关。在连续变量 COX 回归模型中，绝经年龄较晚（HR 0.98，95%CI 0.97-0.99）和生殖寿命较长（HR 0.98，95%CI 0.97-0.99）与全因死亡风险降低相关。绝经年龄较晚（HR 0.98，95%CI 0.97-0.99）和生殖寿命较长（HR 0.98，95%CI 0.97-0.99）与心脏死亡风险降低相关。
女性生殖因素是美国女性 CVDs 的重要危险因素。
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