McNally Sara, Stein Torsten
UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, 4, Ireland.
Institute of Cancer Sciences, College of MVLS, University of Glasgow, Glasgow, UK.
Methods Mol Biol. 2017;1501:1-17. doi: 10.1007/978-1-4939-6475-8_1.
The mouse mammary gland is widely used as a model for human breast cancer and has greatly added to our understanding of the molecular mechanisms involved in breast cancer development and progression. To fully appreciate the validity and limitations of the mouse model, it is essential to be aware of the similarities and also the differences that exist between the mouse mammary gland and the human breast. This introduction therefore describes the parallels and contrasts in mouse mammary gland and human breast morphogenesis from an early embryonic phase through to puberty, adulthood, pregnancy, parturition, and lactation, and finally the regressive stage of involution.
小鼠乳腺被广泛用作人类乳腺癌的模型，极大地增进了我们对乳腺癌发生和发展所涉及分子机制的理解。为了充分认识小鼠模型的有效性和局限性，必须了解小鼠乳腺与人类乳腺之间存在的异同。因此，本引言描述了从小鼠胚胎早期阶段到青春期、成年期、妊娠期、分娩期和哺乳期，最后到退化期的小鼠乳腺和人类乳房形态发生的异同。
