Wolpaw J R, Carp J S, Lee C L
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201.
Neurosci Lett. 1989 Aug 14;103(1):113-9. doi: 10.1016/0304-3940(89)90495-3.
Operant conditioning of the wholly spinal, largely monosynaptic triceps surae H-reflex in monkeys causes changes in lumbosacral spinal cord that persist after removal of supraspinal influence. We evaluated the interaction between post-tetanic potentiation and these memory traces. Animals in which the triceps surae H-reflex in one leg had been increased or decreased by conditioning were deeply anesthetized, and monosynaptic reflexes to L6-S1 dorsal root stimulation were recorded before and after tetanization from both legs for 3 days after thoracic cord transection. Animals remained anesthetized throughout and were sacrificed by overdose. Reflex asymmetries consistent with the effect of H-reflex conditioning were present after transection and persisted through the 3 days of study. Tetanization affected conditioned leg and control leg reflexes similarly. This finding suggests that, while post-tetanic potentiation and probably H-reflex conditioning alter Ia synaptic transmission, the two phenomena have different mechanisms.
对猴子完全脊髓性、主要为单突触的腓肠三头肌H反射进行操作性条件反射，会导致腰骶脊髓发生变化，这种变化在去除脊髓上影响后仍会持续。我们评估了强直后增强与这些记忆痕迹之间的相互作用。通过条件反射使一条腿的腓肠三头肌H反射增强或减弱的动物被深度麻醉，在胸段脊髓横断后3天，记录两侧腿部在强直刺激前后对L6 - S1背根刺激的单突触反射。动物在整个过程中保持麻醉状态，并通过过量给药处死。横断后出现了与H反射条件反射效应一致的反射不对称，并在研究的3天中持续存在。强直刺激对条件反射腿和对照腿反射的影响相似。这一发现表明，虽然强直后增强以及可能的H反射条件反射会改变Ia突触传递，但这两种现象具有不同的机制。
