Semple H C, Liu J C, Peyman G A
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans 70112.
Ophthalmic Surg. 1989 Aug;20(8):588-90.
Piperacillin was injected into the vitreous body of rabbit eyes to evaluate its suitability for intraocular injection and its toxicity on intraocular tissues. Doses ranged from 50 micrograms to 3,000 micrograms. Toxicity was determined through histology and electroretinograms by comparing the piperacillin-injected eyes with eyes injected with balanced saline solution. Retinal toxicity was noted in the outer layer of the retina when 3,000 micrograms was injected intravitreally. No toxicity was noted by histology with 1,500 micrograms of piperacillin. The minimal inhibitory concentration of piperacillin is 800 micrograms/cc for both gram negative and gram positive organisms. The large dose of intravitreal piperacillin tolerated by rabbit eyes makes piperacillin a potentially safe and effective broad spectrum antibiotic for the treatment of bacterial endophthalmitis in human eyes.
将哌拉西林注射到兔眼玻璃体中，以评估其眼内注射的适用性及其对眼内组织的毒性。剂量范围为50微克至3000微克。 通过组织学和视网膜电图，将注射哌拉西林的眼睛与注射平衡盐溶液的眼睛进行比较来确定毒性。 当玻璃体腔内注射3000微克时，在视网膜外层观察到视网膜毒性。 注射1500微克哌拉西林时，组织学检查未发现毒性。 哌拉西林对革兰氏阴性和革兰氏阳性菌的最低抑菌浓度均为800微克/立方厘米。 兔眼能耐受大剂量玻璃体腔注射哌拉西林，这使得哌拉西林成为治疗人类细菌性眼内炎的一种潜在安全有效的广谱抗生素。
