Vieira Débora B, Gamarra Lionel F
Hospital Israelita Albert Einstein, São Paulo, Brazil.
Hospital Israelita Albert Einstein, São Paulo, Brazil; Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil.
Int J Nanomedicine. 2016 Oct 18;11:5381-5414. doi: 10.2147/IJN.S117210. eCollection 2016.
This review summarizes articles that have been reported in literature on liposome-based strategies for effective drug delivery across the blood-brain barrier. Due to their unique physicochemical characteristics, liposomes have been widely investigated for their application in drug delivery and in vivo bioimaging for the treatment and/or diagnosis of neurological diseases, such as Alzheimer's, Parkinson's, stroke, and glioma. Several strategies have been used to deliver drug and/or imaging agents to the brain. Covalent ligation of such macromolecules as peptides, antibodies, and RNA aptamers is an effective method for receptor-targeting liposomes, which allows their blood-brain barrier penetration and/or the delivery of their therapeutic molecule specifically to the disease site. Additionally, methods have been employed for the development of liposomes that can respond to external stimuli. It can be concluded that the development of liposomes for brain delivery is still in its infancy, although these systems have the potential to revolutionize the ways in which medicine is administered.
本综述总结了文献中报道的基于脂质体的有效跨越血脑屏障进行药物递送的策略。由于其独特的物理化学特性，脂质体已被广泛研究用于药物递送和体内生物成像，以治疗和/或诊断神经疾病，如阿尔茨海默病、帕金森病、中风和胶质瘤。已经使用了几种策略将药物和/或成像剂递送至大脑。将肽、抗体和RNA适体等大分子进行共价连接是靶向受体脂质体的有效方法，这使得它们能够穿透血脑屏障并将其治疗分子特异性递送至疾病部位。此外，已采用多种方法来开发能够响应外部刺激的脂质体。可以得出结论，用于脑部递送的脂质体的开发仍处于起步阶段，尽管这些系统有可能彻底改变药物给药方式。
