Wƚodarczyk Marcin, Kasprzyk Jakub, Sobolewska-Wƚodarczyk Aleksandra, Wƚodarczyk Jakub, Tchórzewski Marcin, Dziki Adam, Dziki Ƚukasz
Cancer Biomark. 2016;17(4):411-417. doi: 10.3233/CBM-160657.
Rectal cancer is a major cause of death and an early diagnosis is crucial in decreasing mortality. Previous studies found a relation between chronic inflammation and increased risk of rectal cancer. It was shown that mean platelet volume (MPV) level might be a marker of subclinical inflammatory process in gastrointestinal tract.
To determinate whether MPV could be a useful biomarker of tumor progression in the rectal cancer.
One hundred and three patients with rectal cancer who underwent surgical resection of tumor were enrolled in the study. The control group consisted of 98 healthy subjects.
The association between MPV, tumor stage and clinical status were assessed. The analysis proved that pre-operative MPV level was significantly lower in rectal cancer vs. healthy individuals (10.65 ± 0.79 vs. 11.41 ± 0.76 fL; p < 0.001).Receiver-operating characteristic curve analysis suggested 11.3 as the cut-off value for MPV (sensitivity = 83%; specificity = 54%; AUC = 0.745). Surgical resection of tumor resulted in the increase of the MPV level with statistical significance (10.65 ± 0.79 fL vs. 11.21 ± 0.82 fL; p < 0.001). No relationship was found between the post-operative MPV level in cancer patients and control subjects.
MPV level may be potentially useful and easily available biomarker for monitoring subclinical inflammation related to rectal cancer and predicting tumor progression.
直肠癌是主要的死亡原因之一，早期诊断对于降低死亡率至关重要。先前的研究发现慢性炎症与直肠癌风险增加之间存在关联。研究表明平均血小板体积（MPV）水平可能是胃肠道亚临床炎症过程的一个标志物。
确定MPV是否可能是直肠癌肿瘤进展的有用生物标志物。
103例接受肿瘤手术切除的直肠癌患者纳入本研究。对照组由98名健康受试者组成。
评估了MPV、肿瘤分期和临床状态之间的关联。分析证明，直肠癌患者术前MPV水平显著低于健康个体（10.65±0.79 vs. 11.41±0.76 fL；p<0.001）。受试者工作特征曲线分析表明MPV的截断值为11.3（灵敏度=83%；特异度=54%；AUC=0.745）。肿瘤手术切除导致MPV水平升高，具有统计学意义（10.65±0.79 fL vs. 11.21±0.82 fL；p<0.001）。癌症患者术后MPV水平与对照组之间未发现相关性。
MPV水平可能是用于监测与直肠癌相关的亚临床炎症和预测肿瘤进展的潜在有用且易于获得的生物标志物。
