Kanikarla-Marie Preeti, Lam Michael, Sorokin Alexey V, Overman Michael J, Kopetz Scott, Menter David G
Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Front Oncol. 2018 Apr 20;8:107. doi: 10.3389/fonc.2018.00107. eCollection 2018.
The role of platelets in cancer progression has been well recognized in the field of cancer biology. Emerging studies are elaborating further the additional roles and added extent that platelets play in promoting tumorigenesis. Platelets release factors that support tumor growth and also form heterotypic aggregates with tumor cells, which can provide an immune-evasive advantage. Their most critical role may be the inhibition of immune cell function that can negatively impact the body's ability in preventing tumor establishment and growth. This review summarizes the importance of platelets in tumor progression, therapeutic response, survival, and finally the notion of immunotherapy modulation being likely to benefit from the inclusion of platelet inhibitors.
血小板在癌症进展中的作用在癌症生物学领域已得到充分认识。新兴研究正在进一步阐述血小板在促进肿瘤发生中所起的额外作用及程度。血小板释放支持肿瘤生长的因子，还与肿瘤细胞形成异型聚集体，这可提供免疫逃逸优势。它们最关键的作用可能是抑制免疫细胞功能，而这会对机体预防肿瘤形成和生长的能力产生负面影响。本综述总结了血小板在肿瘤进展、治疗反应、生存方面的重要性，以及免疫治疗调节可能受益于加入血小板抑制剂这一观点。
