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多效生长因子通过增加神经祖细胞的增殖来增强血小板源性生长因子B诱导的胶质瘤发生。

Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells.

作者信息

Zhang Lei, Laaniste Liisi, Jiang Yiwen, Alafuzoff Irina, Uhrbom Lene, Dimberg Anna

机构信息

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, Uppsala, Sweden.

Division of Brain Sciences, Imperial College Faculty of Medicine, London, UK.

出版信息

Oncotarget. 2016 Dec 6;7(49):80382-80390. doi: 10.18632/oncotarget.12983.

DOI:10.18632/oncotarget.12983
PMID:27806344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5348327/
Abstract

Pleiotrophin (PTN) augments tumor growth by increasing proliferation of tumor cells and promoting vascular abnormalization, but its role in early gliomagenesis has not been evaluated. Through analysis of publically available datasets, we demonstrate that increased PTN mRNA expression is associated with amplification of chromosome 7, identified as one of the earliest steps in glioblastoma development. To elucidate the role of PTN in tumor initiation we employed the RCAS/tv-a model that allows glioma induction by RCAS-virus mediated expression of oncogenes in neural progenitor cells. Intracranial injection of RCAS-PTN did not induce glioma formation when administrated alone, but significantly enhanced RCAS-platelet derived growth factor (PDGF)B-induced gliomagenesis. PTN co-treatment augmented PDGFB-induced Akt activation in neural progenitor cells in vitro, and enhanced neural sphere size associated with increased proliferation. Our data indicates that PTN expression is associated with chromosome 7 gain, and that PTN enhances PDGFB-induced gliomagenesis by stimulating proliferation of neural progenitor cells.

摘要

多效生长因子（PTN）通过增加肿瘤细胞增殖和促进血管异常来促进肿瘤生长，但其在早期胶质瘤发生中的作用尚未得到评估。通过对公开数据集的分析，我们证明PTN mRNA表达增加与7号染色体扩增相关，这被认为是胶质母细胞瘤发展的最早步骤之一。为了阐明PTN在肿瘤起始中的作用，我们采用了RCAS/tv-a模型，该模型允许通过RCAS病毒介导的神经祖细胞中癌基因的表达来诱导胶质瘤。单独注射RCAS-PTN时不会诱导胶质瘤形成，但会显著增强RCAS-血小板衍生生长因子（PDGF）B诱导的胶质瘤发生。PTN联合处理增强了体外神经祖细胞中PDGFB诱导的Akt激活，并增加了与增殖增加相关的神经球大小。我们的数据表明PTN表达与7号染色体获得相关，并且PTN通过刺激神经祖细胞增殖来增强PDGFB诱导的胶质瘤发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b7/5348327/aa4dd69c7c5f/oncotarget-07-80382-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b7/5348327/9bf58abc03d3/oncotarget-07-80382-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b7/5348327/bdc2f1eeb5a4/oncotarget-07-80382-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b7/5348327/ad493c054e5d/oncotarget-07-80382-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b7/5348327/aa4dd69c7c5f/oncotarget-07-80382-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b7/5348327/9bf58abc03d3/oncotarget-07-80382-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b7/5348327/bdc2f1eeb5a4/oncotarget-07-80382-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b7/5348327/ad493c054e5d/oncotarget-07-80382-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b7/5348327/aa4dd69c7c5f/oncotarget-07-80382-g004.jpg

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